1-Hydroxypyrene as a biomarker of PAH exposure among subjects living in two separate regions from a steel mill

Lee, Mi‐Sun; Eum, Ki-Do; Zoh, Kyung-Duk; Kim, Taksoo; Pak, Yun-Suk; Paek, Domyung

doi:10.1007/s00420-007-0178-z

Cited by 36 publications

(23 citation statements)

References 43 publications

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“…The gender effect was inconsistent. Several studies reported higher 1-OHP levels for girls (12,16), whereas others reported higher levels for boys (15,26). This study found significantly higher level of 1-OHP for girls when creatinine-adjusted log-transformed values were analyzed (estimate = 0.087; P = 0.031), whereas the difference was not statistically significant with creatinine-unadjusted values (estimate = 0.004; P = 0.941).…”

Section: Discussioncontrasting

confidence: 58%

“…A total of 956 school children participated in biomonitoring part of the PAH exposure assessment study (16). Among the participants, 72 children agreed to take part in the repeated PAH biomarker assessment.…”

Section: Methodsmentioning

confidence: 99%

“…The collected urine samples were stored at freezer (À20jC) in school infirmaries less than 3 d, and then the frozen samples with packed ice were sent to the laboratory for the storage at deep freezer (À70jC) until the final analysis. The 1-OHP in urine was analyzed by a reverse-phase high-performance liquid chromatography method with enzymatic hydrolysis using h-glucuronidase/ arylsulfatase (17) as previously described (16). Excitation and emission wavelengths were 242 and 388 nm, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…Some previous studies used particulate pollutants as a proxy measure of ambient PAHs (16,19). Recent study showed that >90% of the ambient PAHs measured at different regions of Korea were captured in PM 10 fraction (20).…”

Section: Methodsmentioning

confidence: 99%

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Seasonal and Regional Contributors of 1-Hydroxypyrene among Children near a Steel Mill

Lee¹,

Eum²,

Lee³

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Urinary 1-hydroxypyrene (1-OHP) is a biomarker of exposure to polycyclic aromatic hydrocarbons (PAH). Effect of residence on children's PAH exposure was reported among children living near a polluted area. Instead of a snapshot assessment, however, a temporal history of exposure characteristics needs to be assessed in the studies of chronic disease development such as cancer. The urinary 1-OHP measurements were repeated to determine regional effect of ambient air pollution on 1-OHP levels over extended periods. Two sites were chosen: (a) one site located near the steel mill (''nearby'' site) and (b) the other site located at a longer distance from the mill (''remote'' site). Spot urinary 1-OHP levels were measured from 72 children for 3 consecutive days per month, repeated over 9-month period. Compared with remote site, the nearby site had increased the urinary 1-OHP level by 62.3% [95% confidence interval (95% CI), 39.8-88.3%]. Other statistically significant factors that contributed to the level include sex [16.5% (95% CI, 1.2-34.1%) higher for girls than boys], consumption of charbroiled meat [16.5% (95% CI, 1.1-34.2%) higher], and an increase in PM 10 [10.1% (95% CI, 4.8-15.7%) higher for the interquartile range increment]. Controlling for covariates, the 1-OHP levels were increased in the summer and fall compared with winter. The magnitude of the effects of both seasons had diminished after adjusting for PM 10 . This is the first report providing seasonal and regional contributors to environmental PAH exposure, assessed by urinary 1-OHP, with higher 1-OHP levels during summer when ambient pollution was also high. (Cancer Epidemiol Biomarkers Prev 2009;18(1):96 -101)

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Section: Discussioncontrasting

confidence: 58%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Seasonal and Regional Contributors of 1-Hydroxypyrene among Children near a Steel Mill

Lee¹,

Eum²,

Lee³

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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show abstract

“…Children's daily doses of PAHs are often higher than adults' when normalized for body weight. Van Wijnen et al (1996) were the Wrst to report on PAH levels in children, and several subsequent studies have also examined children's exposures (Siwinska et al 1999;Vyskocil et al 2000;Hansen et al 2006;Mucha et al 2006;Lee et al 2007). Diet has been identiWed as the primary source of PAH exposure, but the contribution of indoor and outdoor sources is not clear.…”

Section: Introductionmentioning

confidence: 99%