(+)-(1R,2S,9S)-11-Methyl-7,11-diazatricyclo[7.3.1.0]tridecane

(−)-Cytisine and Derivatives: Synthesis, Reactivity, and Applications

“…Although commercially available from general suppliers, (−)-cytisine is currently an expensive chemical. However, recently, an adaptation of known described methods , allowed its efficient and reproducible extraction from the seeds of Laburnum anagyroides , easily available at low cost from seed producers. This method contributed significantly to the development of (−)-cytisine chemistry with the synthesis of various substituted derivatives (see sections –) and of more complex structures including natural products (see sections and ).…”

“…The yields of isolation from seeds of Laburnum anagyroides vary according to the literature. A reproducible process has been developed by Rouden’s group, and then by O’Brien et al The extraction usually affords up to 1.5 g of pure (−)-cytisine from 100 g of seeds.…”