1′-Methyl-2,2′′-dioxoindoline-3-spiro-2′-pyrrolidine-3′-spiro-3′′-indoline-4′,4′-dicarbonitrile

Abstract

In the title compound, C21H15N5O2, the pyrrolidine ring adopts a twist conformation. Both the oxindole rings are planar [maximum deviations of 0.076 (1) and 0.029 (1) Å in the two rings] and are oriented at a dihedral angle of 72.7 (1)°. The crystal structure is stabilized by C—H⋯O, N—H⋯O, N—H⋯N and C—H⋯π inter­actions.

Crystal structure of 3′-(1H-indole-3-carbonyl)-1′-methyl-2-oxo-4′-(4-oxo-4H-chromen-3-yl)spiro[indoline-3,2′-pyrrolidine]-3′-carbonitrile

“…The geometric parameters of the title molecule ( Fig. 1) agree well with those reported for a similar compound, 1′methyl-2,2′′-dioxoindoline-3-spiro-2′-pyrrolidine-3′-spiro-3′′-indoline-4′,4′-dicarbonitrile (Ramesh et al, 2009). The pyrrolidine ring (N2/C10/C11/C13/C21) adopts a twist conformation on bond N2-C21: puckering parameters and the asymmetry parameters for this ring are q 2 = 0.411 (2) Å, φ 2 = 160.3 3 Fig.…”

“…For the biological activities of indole derivatives, see: Macor et al (1992); Andreani et al (2001); Quetin-Leclercq (1994); Mukhopadhyay et al (1981); Singh et al (2000). For the structure of a very similar compound, see: Ramesh et al (2009 Symmetry codes: (i) x þ 1 2 ; Ày þ 1 2 ; z þ 1 2 ; (ii) Àx þ 1 2 ; y þ 1 2 ; Àz þ 1 2 ; (iii) x; y; z þ 1.…”