2019
DOI: 10.1101/578369
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1-Methyl-tryptophan enantiomers differently affect the cross-talking between mononuclear and tumor cells and interferon-γ production

Abstract: 2The inhibition of the enzyme indoleamine-2,3-dioxygenase (IDO), that catalyzes the 3 oxidation of the amino acid tryptophan to kynurenine (KYN), is considered a good target 4 for immunoadjuvants in antineoplastic therapy. 1-Methyl-tryptophan (1-MT) is the most 5 studied molecule for this purpose. Although L-1-MT is better than D-1-MT in inhibiting 6 IDO, for an unknown reason the D-enantiomer has higher clinical efficacy. Here we took 7 advantage of co-cultures of tumor cells (SK-Mel 19 melanoma line; 1x10 5 … Show more

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