1 Nutritional consequences of gastrointestinal disease

Powell-Tuck, J

doi:10.1016/0950-3528(88)90032-2

Cited by 10 publications

(3 citation statements)

References 57 publications

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“…Malnutrition is mainly due to anorexia and reduced food intake induced by digestive symptoms and pro-inflammatory cytokines, coupled to increased energy expenditure, increased fecal losses, protein-losing enteropathy and malabsorption. However, malnutrition is also found in patients without malabsorption and is probably due to persistent inflammation [21,22]. As shown by several authors [23,24,25], children with active CD have significantly reduced energy intake, which normalizes during remission.…”

Section: Growth Failure In Pediatric Ibdmentioning

confidence: 90%

Impact of Disease and Treatments on Growth and Puberty of Pediatric Patients with Inflammatory Bowel Disease

Ezri¹,

Marques‐Vidal²,

Nydegger³

2012

Digestion

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Growth retardation, associated with delayed puberty, is a frequent feature in pediatric patients with inflammatory bowel disease (IBD), especially with Crohn’s disease. It is mainly induced by malnutrition and the effects of the inflammatory process on the growth hormone/insulin-like growth factor-1 axis or on the growth plate. Therefore, control of disease activity and mucosal healing are paramount to promote growth and adequate pubertal onset. Current therapeutic strategies for maintenance in IBD include anti-inflammatory drugs, immunosuppressives, and, more recently, biologic agents. Although these treatments are efficient in minimizing inflammation and inducing prolonged remission, their long-term effects on growth and final height remain controversial. Furthermore, glucocorticoid therapy, even though very efficient in inducing remission, clearly shows deleterious effects on growth, which is not the case for exclusive enteral nutrition showing comparable results regarding induction of remission. Thus regular assessment of weight, height and pubertal stage is essential in children and adolescents with chronic disease, namely IBD.

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Section: Growth Failure In Pediatric Ibdmentioning

confidence: 90%

Impact of Disease and Treatments on Growth and Puberty of Pediatric Patients with Inflammatory Bowel Disease

Ezri¹,

Marques‐Vidal²,

Nydegger³

2012

Digestion

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“…Malnutrition is among the main postoperative complications of radical subtotal or total gastrectomy for gastric cancer [ 3 4 5 ] and is an important outcome, given the influence of the nutritional status on a patient's quality of life, morbidity, and mortality [ 6 ]. Malnutrition plays a particularly important role in the overall survival of patients with malignant tumors: a poorer nutritional status increases infection susceptibility, delays wound healing, impairs blood clotting, induces vessel wall fragility, and directly increases postoperative complications [ 7 8 9 ].…”

Section: Introductionmentioning

confidence: 99%

Actual 5-Year Nutritional Outcomes of Patients with Gastric Cancer

Kim

Park

et al. 2017

J Gastric Cancer

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PurposeIn this study, we aimed to evaluate the rarely reported long-term nutritional results of patients with gastric cancer after curative gastrectomy.Materials and MethodsWe retrospectively reviewed the prospectively collected medical records of 658 patients who underwent radical gastrectomy with curative intent for gastric cancer from January 2008 to December 2009 and had no recurrences. All patients were followed for 5 years. Nutritional statuses were assessed using measurements of body weight, serum hemoglobin, total lymphocyte count (TLC), protein, albumin, cholesterol, and nutritional risk index (NRI).ResultsPatients who underwent total gastrectomy had lower body weights, hemoglobin, protein, albumin, and cholesterol levels. TLC and NRI valued after the first postoperative year (P<0.05), and lower hemoglobin and NRI valued during the fifth postoperative year than patients who underwent distal gastrectomy (P<0.05). Patients who received adjuvant chemotherapy after gastrectomy had lower hemoglobin, protein, albumin, and cholesterol levels. TLC and NRI valued during the first postoperative year, than those who underwent gastrectomy only (P<0.05). Regarding post-distal gastrectomy reconstruction, those who underwent Roux-en-Y had lower cholesterol levels than did those who underwent Billroth-I and Billroth-II reconstruction at the first and fifth years after gastrectomy, respectively (P<0.05).ConclusionsPatients undergoing total or distal gastrectomy with Roux-en-Y anastomosis or adjuvant chemotherapy after surgery should be monitored carefully for malnutrition during the first postoperative year, and patients undergoing total gastrectomy should be monitored for malnutrition and anemia for 5 years.

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“…The origin of growth retardation is multifactorial, including malnutrition, active inflammation, and steroid therapy among the principal determinants [2,8,9]. Malnutrition is mainly due to anorexia induced by inflammation [10,11], reduced energy intake due to digestive symptoms, and malabsorption of nutrients. Furthermore, CD children with growth failure have normal growth hormone (GH) secretion but diminished plasma concentration of insulin-like growth factor-1 (IGF-1), suggesting a certain degree of GH resistance that may be related to malnutrition and inflammation [12].…”

Section: Introductionmentioning

confidence: 99%

Urinary Metabolic Phenotyping Reveals Differences in the Metabolic Status of Healthy and Inflammatory Bowel Disease (IBD) Children in Relation to Growth and Disease Activity

Martin

Ezri

Cominetti

et al. 2016

IJMS

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Background: Growth failure and delayed puberty are well known features of children and adolescents with inflammatory bowel disease (IBD), in addition to the chronic course of the disease. Urinary metabonomics was applied in order to better understand metabolic changes between healthy and IBD children. Methods: 21 Pediatric patients with IBD (mean age 14.8 years, 8 males) were enrolled from the Pediatric Gastroenterology Outpatient Clinic over two years. Clinical and biological data were collected at baseline, 6, and 12 months. 27 healthy children (mean age 12.9 years, 16 males) were assessed at baseline. Urine samples were collected at each visit and subjected to 1H Nuclear Magnetic Resonance (NMR) spectroscopy. Results: Using 1H NMR metabonomics, we determined that urine metabolic profiles of IBD children differ significantly from healthy controls. Metabolic differences include central energy metabolism, amino acid, and gut microbial metabolic pathways. The analysis described that combined urinary urea and phenylacetylglutamine—two readouts of nitrogen metabolism—may be relevant to monitor metabolic status in the course of disease. Conclusion: Non-invasive sampling of urine followed by metabonomic profiling can elucidate and monitor the metabolic status of children in relation to disease status. Further developments of omic-approaches in pediatric research might deliver novel nutritional and metabolic hypotheses.

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1 Nutritional consequences of gastrointestinal disease

Cited by 10 publications

References 57 publications

Impact of Disease and Treatments on Growth and Puberty of Pediatric Patients with Inflammatory Bowel Disease

Impact of Disease and Treatments on Growth and Puberty of Pediatric Patients with Inflammatory Bowel Disease

Actual 5-Year Nutritional Outcomes of Patients with Gastric Cancer

Urinary Metabolic Phenotyping Reveals Differences in the Metabolic Status of Healthy and Inflammatory Bowel Disease (IBD) Children in Relation to Growth and Disease Activity

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