1-O-alkyl-linked glycerophospholipids of human neutrophils: distribution of arachidonate and other acyl residues in the ether-linked and diacyl species.

Mueller, Howard W.; O’Flaherty, Joseph T.; Greene, Dianne G.; Samuel, Michael P.; Wykle, Robert L.

doi:10.1016/s0022-2275(20)37812-3

Cited by 172 publications

(7 citation statements)

References 34 publications

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“…Since 1973, arachidonic acid has been known to be an abundant fatty acyl substituent accumulating within the alk-1-enyl subclass of GPEtn (26). For example, in the human polymorphonuclear leukocyte, 70% of total arachidonate is esterified to glycerophosphoethanolamine lipids of which 70-80% are plasmenyl at sn-1 (7,27,28). The dynamics of arachidonate remodeling was demonstrated in experiments carried out by incubation of inflammatory cells with low doses of arachidonic acid.…”

Section: Arachidonate Remodelingmentioning

confidence: 99%

“…Plasmalogens are a unique class of choline and ethanolamine glycerophospholipids in that they contain a vinyl ether moiety (Scheme 1) rather than an ester group at the designated first carbon atom of the glycerol backbone (sn-1). These ether phospholipids, properly termed plasmenyl glycerophospholipids, are quite abundant in certain cells and tissues including the red blood cell (3), cardiac tissue (4), nervous tissue (5), spermatozoa (6), as well as inflammatory cells (7). Plasmenyl phospholipids are also found to be reservoirs of polyunsaturated fatty acids such as arachidonic acid and docosahexaenoic acid.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Free-Radical-Induced Oxidation of Arachidonoyl Plasmalogen Phospholipids: Antioxidant Mechanism and Precursor Pathway for Bioactive Eicosanoids

Murphy

2001

Chem. Res. Toxicol.

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Section: Arachidonate Remodelingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Free-Radical-Induced Oxidation of Arachidonoyl Plasmalogen Phospholipids: Antioxidant Mechanism and Precursor Pathway for Bioactive Eicosanoids

Murphy

2001

Chem. Res. Toxicol.

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“…Previous studies have shown that 66% of human neutrophil phospholipids consist of plasmenylethanolamines while only 9% consist of plasmenylcholines [ 30 ]. We did not detect VLC plasmenylcholine molecular species in human neutrophils.…”

Section: Resultsmentioning

confidence: 99%

Identification of novel neutrophil very long chain plasmalogen molecular species and their myeloperoxidase mediated oxidation products in human sepsis

et al. 2021

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Plasmalogens are a class of phospholipids containing vinyl ether linked aliphatic groups at the sn- 1 position. Plasmalogens are known to contain 16- and 18-carbon aliphatic groups at the sn- 1 position. Here, we reveal that the human neutrophil plasmenylethanolamine pool uniquely includes molecular species with very long carbon chain (VLC) aliphatic groups, including 20-, 22- and 24-carbon vinyl ether linked aliphatic groups at the sn- 1 position. We identified these novel VLC plasmalogen species by electrospray ionization mass spectrometry methods. VLC plasmalogens were only found in the neutrophil plasmenylethanolamine pool. During neutrophil activation, VLC plasmenylethanolamines undergo myeloperoxidase-dependent oxidation to produce VLC 2-chlorofatty aldehyde and its oxidation product, 2-chlorofatty acid (2-ClFA). Furthermore, plasma concentrations of VLC 2-ClFA are elevated in human sepsis. These studies demonstrate for the first time VLC plasmenylethanolamine molecular species, their myeloperoxidase-mediated chlorolipid products and the presence of these chlorolipids in human sepsis.

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“…A serendipitous finding in mice in which fatty acid synthase (FAS) was acutely inactivated in adulthood under the control of a ubiquitously expressed promoter, uncovered a potential role of ether lipids in granulopoiesis (381). It was previously shown that ether lipids account for more than 50 % of the membrane glycerophospholipids in neutrophils (382). The inhibition of lipogenesis resulted in neutropenia without affecting the differentiation of granulocyte precursors (381).…”

Section: The Innate Immune Systemmentioning

confidence: 99%

The physiological functions of human peroxisomes

Wanders

Baes

Ribeiro

et al. 2023

Physiological Reviews

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Peroxisomes are subcellular organelles which play a central role in human physiology by catalyzing a range of unique metabolic functions. The importance of peroxisomes for human health is exemplified by the existence of a group of usually severe diseases caused by an impairment in one or more peroxisomal functions. Among others these include the Zellweger spectrum disorders, X-linked adrenoleukodystrophy and Refsum disease. In order to fulfill their role in metabolism, peroxisomes require the continued interaction with other subcellular organelles including lipid droplets, lysosomes, the endoplasmic reticulum, and mitochondria. In recent years it has become clear that the metabolic alliance between peroxisomes and other organelles requires the active participation of tethering proteins to bring the organelles physically closer together thereby achieving efficient transfer of metabolites. This review intends to describe the current state of knowledge about the metabolic role of peroxisomes in humans with particular emphasis on the metabolic partnership between peroxisomes and other organelles and the consequences of genetic defects in these processes. We will also describe the biogenesis of peroxisomes and the consequences of the multiple genetic defects therein. In addition, we will discuss the functional role of peroxisomes in different organs and tissues and will include relevant information derived from model systems notably peroxisomal mouse models. Finally, we will pay particular attention to a hitherto underrated role of peroxisomes in viral infections.

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1-O-alkyl-linked glycerophospholipids of human neutrophils: distribution of arachidonate and other acyl residues in the ether-linked and diacyl species.

Cited by 172 publications

References 34 publications

Free-Radical-Induced Oxidation of Arachidonoyl Plasmalogen Phospholipids: Antioxidant Mechanism and Precursor Pathway for Bioactive Eicosanoids

Free-Radical-Induced Oxidation of Arachidonoyl Plasmalogen Phospholipids: Antioxidant Mechanism and Precursor Pathway for Bioactive Eicosanoids

Identification of novel neutrophil very long chain plasmalogen molecular species and their myeloperoxidase mediated oxidation products in human sepsis

The physiological functions of human peroxisomes

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