1 Pharmacologically Active Pyridazine Derivatives. Part 1

Analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl)pyridazin-(2H)-3-one derivatives

“…Therefore, there is an increasing need for identification of lead structures that may be of use in designing new, potent drugs with less toxic effects (Takaya et al, 1979;Heinisch et al, 1990). In addition, some pyridazinone derivatives have been found to exhibit potent NSAIDs activity through the selective COX-2 inhibitory mechanism (Chintakunta et al, 2002) and some pyridazinone compounds were also found to be more potent than reference drugs.…”

Crystal structure of 6-(benz-1H-imidazol-2-yl)-2,3-dihydropyridazin-3-one —N,N-dimethylformamide (1:1), C14H15N5O2

“…Pyridazinea nd pyridazin-3-one moietiesa re known "pharmacophores" and compounds involving them find considerable use as herbicides and drugs (for someo ft heir pharmaceutical application, see [2,3]). In theframework of our current studies, the title compound, C 11 H 8 N 4 O×C 3 H 7 NO, was isolated as theD MF monosolvate.…”

Crystal structure of 2-aminophenylammonium— 6-oxo-1,6-dihydropyridazine- 3-carboxylate (1:1), C11H12N4O3

“…Derivated pyridazines are known biologically active compounds which find their use as herbicides and drugs (for examples of their pharmaceutical application, see [2,3]). In theframework of our current studies, the title salt, [C 6 …”