1985
DOI: 10.1016/s0300-595x(85)80036-0
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1 The pathogenesis of graves' disease

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Cited by 23 publications
(9 citation statements)
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“…Peripheral blood T cells responded to both (Table 3), further emphasizing the degree of antigenic selection in the thyroid. It is of interest that none of the HLA restriction elements involved with the presentation of the TPO epitopes defined here was DR3, the HLA class II element that has been most frequently associated in epidemiological studies with increased susceptibility to Graves disease (1) and that was also present in this individual. This contrasts with the view that the basis for genetic associations between HLA elements and autoimmune disease is the requirement of these elements in presentation of autoantigen.…”
mentioning
confidence: 95%
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“…Peripheral blood T cells responded to both (Table 3), further emphasizing the degree of antigenic selection in the thyroid. It is of interest that none of the HLA restriction elements involved with the presentation of the TPO epitopes defined here was DR3, the HLA class II element that has been most frequently associated in epidemiological studies with increased susceptibility to Graves disease (1) and that was also present in this individual. This contrasts with the view that the basis for genetic associations between HLA elements and autoimmune disease is the requirement of these elements in presentation of autoantigen.…”
mentioning
confidence: 95%
“…Graves disease is a form of thyroid autoimmunity characterized by lymphocytic infiltration of the thyroid and stimulation of the gland by anti-thyrotropin (TSH) receptor autoantibodies resulting in thyrotoxicosis (1). Frequently, high titers of autoantibodies to other thyroidspecific proteins, including thyroglobulin (Tg) and the thyroid microsomal antigen (TMA; ref.…”
mentioning
confidence: 99%
“…1 The cause of the disease is considered to be increased circulating levels of thyroid-stimulating immunoglobulins, and the disease is associated with HLA haplotype A1, B8, DR3 in occidentals nd Bw35 in orientals. 2 As with most other thvroid disorders, the incidence of Graves' disease is three to five times higher in females than in males.…”
mentioning
confidence: 99%
“…Lymphoid infiltration, sometimes associated with germinal center formation, is often seen in patients with classic hyperthyroid Graves' disease (4). Usually, the lymphoid cells are strewn in the interfollicular stroma and do not encroach on the follicles themselves.…”
Section: Diffuse Toxic Goitermentioning
confidence: 99%