1-year follow-up study of cognitive function in first-episode non-affective psychosis

Rodríguez-Sánchez, José Manuel; Pérez-Iglesias, Rocí­o; González‐Blanch, César; Pelayo-Terán, José María; Mata, Ignacio; Martínez, Obdulia; Sánchez-Cubillo, Ignacio; Vázquez‐Barquero, José Luís; Crespo‐Facorro, Benedicto

doi:10.1016/j.schres.2008.05.020

Cited by 43 publications

(27 citation statements)

References 41 publications

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“…The generalizability is supported by stability in the incidence rate in this study and the previous Treatment and Intervention study (TIPS) (REF) which varied between 11 and 14/ 100000. The response rate of 81% for 1-year follow up is also in line with TIPS (Melle et al, 2004) and other studies (Addington et al, 2007; Malla et al, 2002a) as is the response rate for neuropsychological assessment (Rodriguez-Sanchez et al, 2008; Rund et al, 2007). …”

Section: Discussionsupporting

confidence: 88%

Apathy, poor verbal memory and male gender predict lower psychosocial functioning one year after the first treatment of psychosis

Færden¹,

Barrett²,

Nesvåg³

et al. 2013

Psychiatry Research

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Background Apathy is a negative symptom associated with poor psychosocial functioning in schizophrenia but has not been sufficiently studied as predictor of poor functioning in first episode psychosis (FEP). Objective The main aim of the current study was to evaluate if apathy predicts poor functioning after 1 year in FEP patients in the context of other clinical variables with influence on outcome. Method Sixty-four FEP patients completed an extensive clinical and neuro-psychological test battery at baseline and 1-year follow-up. Symptoms were assessed with the Positive and Negative Syndrome scale (PANSS), apathy with the shortened Apathy Evaluation Scale (AES-C-12) and psychosocial functioning with the functioning score from the split version of the Global Assessment of Functioning scale (GAF-F). Results High levels of apathy, poor verbal memory and being male were the baseline variables that best predicted poor functioning at 1-year follow-up, explaining 34% of the variance in GAF-F. When PANSS negative factor was included in the analysis, the significance of AES-C-12 diminished. Conclusion These findings points to a robust role for apathy among the negative symptoms in the development of persisting psychosocial dysfunction in FEP and supports the current effort in targeting motivation to improve functioning.

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Section: Discussionsupporting

confidence: 88%

Apathy, poor verbal memory and male gender predict lower psychosocial functioning one year after the first treatment of psychosis

Færden¹,

Barrett²,

Nesvåg³

et al. 2013

Psychiatry Research

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“…Several previous studies similarly assessed cognitive functioning in drug-naive patients with psychosis (for example, see the studies by Chan and colleagues 59 and Rodríguez-Sánchez and colleagues 60 ), and their results support that patients with first-episode psych osis can undergo brief cognitive assessment. Nonetheless, we enrolled only patients who were able to give their consent to receive further treatment.…”

Section: Limitationsmentioning

confidence: 64%

Cognitive control deficit in patients with first-episode schizophrenia is associated with complex deviations of early brain development

Plaze

Oppenheim

Gaillard

et al. 2017

JPN

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“…To date, investigations of a relationship between neurocognitive course and recurrent psychotic episodes are not reported in studies of FEP patients with a longitudinal multi-assessment design. Consequently, it is still unclear whether cognitive dysfunctions remain stable, decrease, or fluctuate (Rodriguez-Sanchez et al, 2008), and if there are systematic differences between clinically defined subgroups (Knoll et al, 1998). …”

Section: Introductionmentioning

confidence: 99%

Ten year neurocognitive trajectories in first-episode psychosis

Barder

Sundet

Rund

et al. 2013

Front. Hum. Neurosci.

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Objective: Neurocognitive impairment is commonly reported at onset of psychotic disorders. However, the long-term neurocognitive course remains largely uninvestigated in first episode psychosis (FEP) and the relationship to clinically significant subgroups even more so. We report 10 year longitudinal neurocognitive development in a sample of FEP patients, and explore whether the trajectories of cognitive course are related to presence of relapse to psychosis, especially within the first year, with a focus on the course of verbal memory.Method: Forty-three FEP subjects (51% male, 28 ± 9 years) were followed-up neurocognitively over five assessments spanning 10 years. The test battery was divided into four neurocognitive indices; Executive Function, Verbal Learning, Motor Speed, and Verbal Fluency. The sample was grouped into those relapsing or not within the first, second and fifth year.Results: The four neurocognitive indices showed overall stability over the 10 year period. Significant relapse by index interactions were found for all indices except Executive Function. Follow-up analyses identified a larger significant decrease over time for the encoding measure within Verbal Memory for patients with psychotic relapse in the first year [F(4, 38) = 5.8, p = 0.001, η2 = 0.40].Conclusions: Main findings are long-term stability in neurocognitive functioning in FEP patients, with the exception of verbal memory in patients with psychotic relapse or non-remission early in the course of illness. We conclude that worsening of specific parts of cognitive function may be expected for patients with on-going psychosis, but that the majority of patients do not show significant change in cognitive performance during the first 10 years after being diagnosed.

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1-year follow-up study of cognitive function in first-episode non-affective psychosis

Cited by 43 publications

References 41 publications

Apathy, poor verbal memory and male gender predict lower psychosocial functioning one year after the first treatment of psychosis

Apathy, poor verbal memory and male gender predict lower psychosocial functioning one year after the first treatment of psychosis

Cognitive control deficit in patients with first-episode schizophrenia is associated with complex deviations of early brain development

Ten year neurocognitive trajectories in first-episode psychosis

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