10 % fluorescein sodium vs 1 % isosulfan blue in breast sentinel lymph node biopsy

Lang, Ren; Liu, Zhao; Liang, Mengdi; Wang, Li; Song, Xingli; Wang, Shui

doi:10.1186/s12957-016-1031-1

Cited by 8 publications

(4 citation statements)

References 19 publications

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“…Since then, there has been considerable progress in the use of such “lymphatic tracers” but, in general, these tracers exhibit light staining, poor diffusion, and nonuniform particles, which can lead to misjudgments by surgeons. 15 , 22 Moreover, the injection time of pigments or lymphatic tracing methods is not easy to control.…”

Section: Discussionmentioning

confidence: 99%

Clinical application of carbon nanoparticles in curative resection for colorectal carcinoma

Wang

Zhou

Zheng

et al. 2017

OTT

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PurposeTo explore the potential of carbon nanoparticles (CNs) for the intraoperative detection of positive and negative lymph nodes in the treatment of colorectal cancer.Patients and methodsThe clinical data of 470 patients undergoing surgical procedures for colorectal cancer from June 2010 to February 2013 were analyzed retrospectively. The patients were divided into the CN group (183 males and 161 females; mean age, 58.6±12.4 years), who were given a CN suspension, and the control group (78 males and 48 females; mean age, 59.1±12.2 years), who were not given a CN suspension. The operative time, blood loss, number of lymph nodes detected/positive lymph nodes, and prevalence of postoperative complications were compared between the two groups. Three years after surgery, 444 cases (327 cases in the CN group and 117 cases in the control group) were interviewed, with the remaining 26 cases lost to follow-up. With regard to tumor, node, metastasis staging, the survival and prevalence of recurrence in each group at 3 years were analyzed.ResultsThe number of positive lymph nodes was higher and the prevalence of blood loss was lower in the CN group than in the control group (p<0.05). There were no significant differences in the operative time, number of lymph nodes detected, or the prevalence of postoperative complications, survival, metastasis, or recurrence between the two groups at 3 years (p>0.05).ConclusionThe application of CNs is convenient for the detection of lymph nodes to reduce blood loss and increase the probability of detecting positive lymph nodes accurately and rapidly.

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Section: Discussionmentioning

confidence: 99%

Clinical application of carbon nanoparticles in curative resection for colorectal carcinoma

Wang

Zhou

Zheng

et al. 2017

OTT

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“…Unlike the proteins, radiological tools are expensive, ranging from $280 for HRCT to $807 for MRC ( 6 ). On the other hand, an ampule of 10% fluorescein costs only $1.7 ( 25 ), and is widely available, as it is used in many ophthalmic procedures and brain tumor surgeries ( 26 ).…”

Section: Discussionmentioning

confidence: 99%

Topical Intranasal Fluorescein to Diagnose and Localize Cerebrospinal Fluid Leak: A Systematic Review

Albaharna¹,

Alshareef²,

Alromaih³

et al. 2021

TAO

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Objective: This study evaluates the available evidence regarding using topical intranasal fluorescein (TINF) to diagnose and localize nasal cerebrospinal fluid (CSF) leak. Methods: A literature search was conducted through PubMed, the Cochrane Database, Scopus, and Ovid to identify the articles providing insight into using TINF to diagnose CSF leak preoperatively or to localize the leak intraoperatively. The articles from the database were screened and filtered by two authors according to the selection criteria. A spreadsheet was created to collect the data including demographic characteristics, the sensitivity and specificity of TINF for diagnosing and localizing a CSF leak, the protocol of applying TINF, and the complications. Results: After excluding duplicates and articles that did not meet our selection criteria, we included five reports in the final analysis. The average age of the 94 participants was 39.5, and there was an equal distribution of males and females. The sensitivity of TINF to make a preoperative diagnosis of CSF leak was 100%, and it was 97% to localize the site intraoperatively. Complications associated with TINF were not reported in any of the reports. This review showed a grade C recommendation based on five case series. Conclusion: Based on the current evidence, TINF cannot be recommended for standard clinical practice. It can, however, be considered in situations where other gold standard tools are unavailable since it is feasible and easy to use. A standardized control trial should be conducted to yield additional unbiased evidence.

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“…Subsequently, several authors also reported the use of fluorescein dye in breast cancer for SLN biopsy detection. [25][26][27][28] Earlier margin assessments methods are described in review article 29 and as per author's knowledge no one has used fluorescein dye in fluorescence spectroscopy for breast cancer margin assessment during surgery before our study.…”

Section: Theoretical Backgroundmentioning

confidence: 99%

Point‐of‐care devices based on fluorescence imaging and spectroscopy for tumor margin detection during breast cancer surgery: Towards breast conservation treatment

et al. 2023

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Objective Fluorescence‐based methods are highly specific and sensitive and have potential in breast cancer detection. Simultaneous fluorescence imaging and spectroscopy during intraoperative procedures of breast cancer have great advantages in detection of tumor margin as well as in classification of tumor to healthy tissues. Intra‐operative real‐time confirmation of breast cancer tumor margin is the aim of surgeons, and therefore, there is an urgent need for such techniques and devices which fulfill the surgeon's priorities. Methods In this article, we propose the development of fluorescence‐based smartphone imaging and spectroscopic point‐of‐care multi‐modal devices for detection of invasive ductal carcinoma in tumor margin during removal of tumor. These multimodal devices are portable, cost‐effective, noninvasive, and user‐friendly. Molecular level sensitivity of fluorescence process shows different behavior in normal, cancerous and marginal tissues. We observed significant spectral changes, such as, red‐shift, full‐width half maximum (FWHM), and increased intensity as we go towards tumor center from normal tissue. High contrast in fluorescence images and spectra are also recorded for cancer tissues compared to healthy tissues. Preliminary results for the initial trial of the devices are reported in this article. Results A total 44 spectra from 11 patients of invasive ductal carcinoma (11 spectra for invasive ductal carcinoma and rest are normal and negative margins) are used. Principle component analysis is used for the classification of invasive ductal carcinoma with an accuracy of 93%, specificity of 75% and sensitivity of 92.8%. We obtained an average 6.17 ± 1.66 nm red shift for IDC with respect to normal tissue. The red shift and maximum fluorescence intensity indicates p < 0.01. These results described here are supported by histopathological examination of the same sample. Conclusion In the present manuscript, simultaneous fluorescence‐based imaging and spectroscopy is accomplished for the classification of IDC tissues and breast cancer margin detection.

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10 % fluorescein sodium vs 1 % isosulfan blue in breast sentinel lymph node biopsy

Cited by 8 publications

References 19 publications

Clinical application of carbon nanoparticles in curative resection for colorectal carcinoma

Clinical application of carbon nanoparticles in curative resection for colorectal carcinoma

Topical Intranasal Fluorescein to Diagnose and Localize Cerebrospinal Fluid Leak: A Systematic Review

Point‐of‐care devices based on fluorescence imaging and spectroscopy for tumor margin detection during breast cancer surgery: Towards breast conservation treatment

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