10 Gas phase organic ion–molecule reaction chemistry

Gas Chromatographic-Ion Trap Mass Spectrometric Analysis of Volatile Organic Compounds by Ion–Molecule Reactions Using the Electron-Deficient Reagent Ion CCl3+

“…Over the past decade, various mass spectrometric methods based on ion-molecule reactions have been explored in order to study organic reactions [1][2][3] and give deep insights into the fundamental physical and chemical properties of gas-phase ions such as gas-phase acidities, basicities, and bond energies [4][5][6]. Furthermore, ion-molecule reactions are also regarded as a useful tool for solving challenging analytical problems because these reactions are often highly selective and extremely fast, as well as combined with chromatographic separation methods for qualitative analysis of target compounds in complicated samples.…”

Organic gas-phase ion chemistry

“…These contributions address ionic hydrogen bonds, 25 the role of water in ionic and radical processes, 26 molecular and chiral recognition, 27,28 ion-ion chemistry, 29 velocity modulation spectroscopy of ions, 30 infrared spectroscopy of metal ion complexes, 31 hydration of small peptides, 32 all metal aromaticity, 33 catalytic reactions of small metal clusters, 34 divalent metal complex ion reactivity, 35 and fundamental organic reaction studies carried out in a quadrupole ion trap. 36 The organization of this review is in keeping with recent contributions to this series by Wenthold, [37][38][39] O'Hair, 40,41 and Gronert, 42 and is presented in the following broad categories: Biological chemistry, Thermochemistry, Ion spectroscopy, Reactions of anions, cations, and radical ions, Nucleophilic substitution, addition, and elimination, Reactions of organic compounds with small inorganic ions, Chiral recognition and host-guest chemistry, and Cluster chemistry.…”

9 Organic gas phase ion chemistry

“…(16)]; or alternatively, regiospecific proton transfer to isomerize into three different ter-body complexes formed of water, isobutene and ionized enol, which can then react to either form (ii) the solvated enol ion [eqn. (17)]; or (iii) undergo a cycloaddition-cycloreversion process to form a new enol ion [eqn. (18)].…”

“…15 Details of instrumentation, techniques and past reviews of gas phase organic ion chemistry are not given here -readers are directed to last year's review 1 and previous introductions by Gronert. 16, 17 A number of reviews and books have appeared in 2001 that reflect the rich areas of organic gas phase ion chemistry. Topics covered include: a discussion of the units in mass spectrometry; 18 methods of generating gas phase ions; 19-21 mass analysers; 22,23 coupling of chromatography techniques to MS; 24,25 aspects of unimolecular fragmentation reactions; 26,27 collisions with surfaces; 28 charge permutation reactions 29 including charge stripping of anions; 30 mulitpole bound molecular anions; 31 crossed beam methods; 32 high temperature conditions; 33 complex formation and the influence of vibrations; 34 applications of proton transfer reactions; 35 base induced 1,4 elimination reactions; 36 formation of cumulenes and related systems; 37 the neutral products from gas phase carbocation rearrangements; 38 thermochemistry of ions 39 including proton transfer; 40 photodetachement of multiply charged anions; 41 photodissociation of ions; 42,43 REMPI photoelectron spectroscopy; 44 techniques to probe the "conformational landscape" of small biomolecules in the gas phase; 45 gas phase spectroscopy of biomolecules; 46,47 aspects of cluster ions; 48,49 use of ion-mobility measurements; 50 molecular recognition and supramolecular chemistry; 51,52 non-covalent complexes in the gas phase including cyclodextrin complexes, 53 RNA and DNA complexes 54 and oligonucleotide complexes with drugs, metals and proteins; 55 computational chemistry as an aid to experiment; 56, 57 and aspects of mass spectrometry in drug discovery 58-61 including a book 58 which has a review on fundamental ion chemistry and fragmentation.…”