10-Gy Single-Fraction Pelvic Irradiation for Palliation and Life Prolongation in Patients with Cancer of the Cervix and Corpus Uteri

Onsrud, Mathias; Hagen, Bjørn; Strickert, Trond

doi:10.1006/gyno.2001.6233

Cited by 56 publications

(34 citation statements)

References 10 publications

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“…Overall late toxicity rate was 6-12 % in these series, occurring 9-10 months after treatment [17,18]. It is difficult to assess the true rate of late complications from these 10-Gy fractions.…”

Section: Vaginal Bleedingmentioning

confidence: 81%

“…Onsrud et al [18] reported on 64 patients using monthly 10-Gy fractions, with the majority of patients receiving two fractions. Bleeding cessation was seen in 90 % of patients.…”

Section: Vaginal Bleedingmentioning

confidence: 99%

“…This may translate into lower rates of both acute and late treatment toxicity. Late complications were typically seen after 9 months, which led several authors to conclude that this treatment regime should be limited to patients with life expectancy less than 9 or 12 months [17,18]. Alternately, as a correlation between symptom response and number of fractions was not always seen, the third fraction could be omitted to reduce the likelihood of late toxicity [20].…”

Section: Vaginal Bleedingmentioning

confidence: 99%

“…Alternately, as a correlation between symptom response and number of fractions was not always seen, the third fraction could be omitted to reduce the likelihood of late toxicity [20]. Survival can be difficult to accurately predict however; for example, Onsrud et al [18] found that 28 % of patients with an expected survival of <12 months actually lived longer than this.…”

Section: Vaginal Bleedingmentioning

confidence: 99%

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Palliative pelvic radiotherapy for gynaecologic cancer

Skliarenko

Barnes

2012

J Radiat Oncol

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Background Radiotherapy delivered with palliative intent can relieve many of the distressing pelvic symptoms associated with advanced, recurrent, or metastatic gynaecologic cancer.Results Series in the literature mainly focus on the outcomes of bleeding and pain for which high response rates are seen. This article reviews the hypofractionated palliative radiotherapy regimes and outcomes reported in the literature. Conclusion Treatment should be individualized for each patient, taking into account symptom burden and etiology, risk of toxicity, performance status and life expectancy.

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Section: Vaginal Bleedingmentioning

confidence: 81%

“…Onsrud et al [18] reported on 64 patients using monthly 10-Gy fractions, with the majority of patients receiving two fractions. Bleeding cessation was seen in 90 % of patients.…”

Section: Vaginal Bleedingmentioning

confidence: 99%

Section: Vaginal Bleedingmentioning

confidence: 99%

Section: Vaginal Bleedingmentioning

confidence: 99%

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Palliative pelvic radiotherapy for gynaecologic cancer

Skliarenko

Barnes

2012

J Radiat Oncol

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“…Cihoric et al reported that bleeding control improved in 94.7% of patients with uterovaginal cancer at the end of RT [10]. Other reports have described the excellent efficacy for hemostasis with RT doses and fractions in a single fraction or multiple monthly 10-Gy fractions [11,12]. The radiosensitivity of squamous cell carcinoma, which is the major histological type of uterovaginal cancer, may at least partly explain this relatively good response to HRT, as compared to bleeding cancers in other organs.…”

Section: Discussionmentioning

confidence: 99%

A retrospective study of the effectiveness of hemostatic radiotherapy with conventional fractionation in patients with advanced cancer

Nomoto¹,

Akai²,

Nomiyama³

et al. 2015

J Cancer Res Ther.

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Palliative interventions for controlling vaginal bleeding in advanced cervical cancer

Eleje

Eke

Igberase³

et al. 2015

Cochrane Database of Systematic Reviews

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There is no evidence from controlled trials to support or refute the use of any of the proposed interventions compared with radiotherapy. Therefore, the choice of intervention will be based on local resources. Radiotherapy techniques for managing vaginal bleeding are not readily available in resource-poor settings, where advanced cases of cervical cancer are predominant. Thus, this systematic review identified the need for a randomised controlled trial assessing the benefits and risks of palliative treatments for vaginal bleeding in women with advanced cervical cancer.

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10-Gy Single-Fraction Pelvic Irradiation for Palliation and Life Prolongation in Patients with Cancer of the Cervix and Corpus Uteri

Cited by 56 publications

References 10 publications

Palliative pelvic radiotherapy for gynaecologic cancer

Palliative pelvic radiotherapy for gynaecologic cancer

A retrospective study of the effectiveness of hemostatic radiotherapy with conventional fractionation in patients with advanced cancer

Palliative interventions for controlling vaginal bleeding in advanced cervical cancer

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