10-Hydroxy-2-decenoic acid inhibiting the proliferation of fibroblast-like synoviocytes by PI3K–AKT pathway

Wang, Jianguang; Zhang, Wei; Zou, Hai; Lin, Yaoyao; Lin, Ke; Zhou, Zhonghao; Qiang, Jiaping; Lin, Jialiang; Chuka, Chifundo Martha; Ge, Ren‐Shan; Zhao, Shujiang; Yang, Xinyu

doi:10.1016/j.intimp.2015.05.036

Cited by 16 publications

(16 citation statements)

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“…Histone deacetylase inhibition by 10-HDA is thought to reactivate the expression of epigenetically silenced genes in mammalian cells, leading to the hypothesis that a similar effect could be at the basis of caste switching in bees (Spannhoff et al, 2011). Modifications of histone acetylation have also emerged from a study showing 10-HDA inhibition of fibroblast-like synoviocytes from rheumatoid arthritis patients, suggesting potential therapeutic effects against chronic inflammation degenerative disease (Wang et al, 2015). …”

Section: Royal Jellymentioning

confidence: 99%

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

et al. 2017

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Honeybees produce honey, royal jelly, propolis, bee venom, bee pollen, and beeswax, which potentially benefit to humans due to the bioactives in them. Clinical standardization of these products is hindered by chemical variability depending on honeybee and botanical sources, but different molecules have been isolated and pharmacologically characterized. Major honey bioactives include phenolics, methylglyoxal, royal jelly proteins (MRJPs), and oligosaccharides. In royal jelly there are antimicrobial jelleins and royalisin peptides, MRJPs, and hydroxy-decenoic acid derivatives, notably 10-hydroxy-2-decenoic acid (10-HDA), with antimicrobial, anti-inflammatory, immunomodulatory, neuromodulatory, metabolic syndrome preventing, and anti-aging activities. Propolis contains caffeic acid phenethyl ester and artepillin C, specific of Brazilian propolis, with antiviral, immunomodulatory, anti-inflammatory and anticancer effects. Bee venom consists of toxic peptides like pain-inducing melittin, SK channel blocking apamin, and allergenic phospholipase A2. Bee pollen is vitaminic, contains antioxidant and anti-inflammatory plant phenolics, as well as antiatherosclerotic, antidiabetic, and hypoglycemic flavonoids, unsaturated fatty acids, and sterols. Beeswax is widely used in cosmetics and makeup. Given the importance of drug discovery from natural sources, this review is aimed at providing an exhaustive screening of the bioactive compounds detected in honeybee products and of their curative or adverse biological effects.

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Section: Royal Jellymentioning

confidence: 99%

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

et al. 2017

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“…Phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) signalling pathway was reported in SFs; there, it showed an unusual activation state, which might lead to the imbalance of SFs proliferation and apoptosis. It was also shown that the gene coding for the PIK3R2 was targeted by microRNA-126 [ 34 , 35 ]. Gao et al aimed to explore the associations between miR-126, PIK3R2 gene and PI3K/AKT signalling pathway in RASFs [ 36 ].…”

Section: Autoimmune Diseases Related To Mir-126mentioning

confidence: 99%

Involvement of miR-126 in autoimmune disorders

et al. 2018

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BackgroundMicro-RNA represent a great family of small non-condign ribonucleic acid molecules; in particular microRNA-126 is an important member of this family and is expressed in many human cells such as cardiomyocytes, endothelial and lung cells. Some studies have shown the implication of miR-126 in cancer, but recently significant progresses have also been made in determining the role of miR-126 regulating immune-related diseases; probably, in a near future, they could potentially serve as diagnostic biomarkers or therapeutic targets.ObjectiveThe purpose of this review is to investigate the role of miR-126 in autoimmune diseases, so as to offer innovative therapies.ResultsAccording literature, it was concluded that miRNAs, especially miR-126, are involved in many pathologies and that their expression levels increase in autoimmune diseases because they interfere with the transcription of the proteins involved. Since microRNAs can be detected from several biological sources, they may be attractive as potential biomarkers for the diagnosis, prognosis, disease activity and severity of various diseases. In fact, once confirmed the involvement of miR-126 in autoimmune diseases, it was speculated that it could be used as a promising biomarker. These discovers implicate that miR-126 have a central role in many pathways leading to the development and sustain of autoimmune diseases. Its key role make this microRNA a potential therapeutic target in autoimmunity.ConclusionAlthough miR-126 relevant role in several immune-related diseases, further studies are needed to clear its molecular mechanisms; the final step of these novel researches could be the blockage or the prevention of the diseases onset by creating of new targeted therapy.

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“…Other general inhibitors, some of which are in clinical trials for various cancers, decrease RA FLS proliferation or disease severity in mouse models of RA and include phenylbutyrate [58], romidepsin (FK228) (Figure 3) [61], entinostat (MS-275) [62], zolinza (suberoylanilide hydroxamic acid) [63] and 10-hydroxy-2-decanoic acid [64]. Although promising, HDACs have different patterns of expression and function in RA FLS as previously discussed, and so a specific HDAC inhibitor profile could be important.…”

Section: Hdac Inhibition In Ra Fls and In Arthritismentioning

confidence: 99%

Epigenetic Alterations in Rheumatoid Arthritis Fibroblast-Like Synoviocytes

2017

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Rheumatoid arthritis is an immune-mediated disease that primarily affects diarthrodial joints. Susceptibility and severity of this disease are influenced by nongenetic factors, such as environmental stress, suggesting an important role of epigenetic changes. In this review, we summarize the epigenetic changes (DNA methylation, histone modification and miRNA expression) in fibroblast-like synoviocytes, which are the joint-lining mesenchymal cells that play an important role in joint inflammation and damage. We also review the effects of these epigenetic changes on rheumatoid arthritis pathogenesis and discuss their therapeutic potential.

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10-Hydroxy-2-decenoic acid inhibiting the proliferation of fibroblast-like synoviocytes by PI3K–AKT pathway

Cited by 16 publications

References 50 publications

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

Involvement of miR-126 in autoimmune disorders

Epigenetic Alterations in Rheumatoid Arthritis Fibroblast-Like Synoviocytes

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