10-Year trajectories of depressive symptoms and subsequent brain health in middle-aged adults

Schuurmans, Isabel K.; Lamballais, Sander; Zou, Runyu; Muetzel, Ryan L.; Hillegers, Manon H. J.; Cecil, Charlotte A. M.; Luik, Annemarie I.

doi:10.1016/j.jpsychires.2022.12.018

Cited by 4 publications

(3 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Very few studies have characterized depressive symptoms from early to mid-adulthood and their association to midlife cognitive and brain outcomes. Midlife represents a critical period when cognitive trajectories may start to diverge in relation to risk factors; thus, understanding the role of depressive symptoms during this life stage One study including 1676 expectant in their 30 s, found that longitudinal depressive symptoms trajectories over 10 years were only minimally associated with brain health markers (brain volumes and cortical thickness) in middle age [33]. This is contrary to what we found in our study, whereby the steady high depressive symptom group exhibited lower volumes of the amygdala and entorhinal cortex.…”

Section: Discussionmentioning

confidence: 99%

Trajectories in depressive symptoms and midlife brain health

Dintica,

Habes,

Schreiner

et al. 2024

Transl Psychiatry

View full text Add to dashboard Cite

Depressive symptoms may either be a risk factor or prodromal to dementia. Investigating this association in midlife may help clarify the role of depression in cognitive aging. We aimed to identify trajectories in depressive symptoms in early to mid-life and related cognitive and brain outcomes in midlife. This study includes 3944 Black and White participants (ages 26−45 years at baseline) from the Coronary Artery Risk Development in Young Adults (CARDIA) study with 20 years of follow-up. Depressive symptoms were assessed using the Center for Epidemiological Studies Depression scale at five time points over 20 years. Growth mixture modeling (GMM) was used to identify depressive symptom trajectories. Participants completed a neuropsychological battery 20 years after baseline, including the Digit Symbol Substitution Test (DSST), Rey-Auditory Verbal Learning Test (RAVLT), Stroop Test, Montreal Cognitive Assessment (MoCA), and category and letter fluency tests. A sub-sample of participants (n = 662) underwent brain magnetic resonance imaging (MRI) to characterize gray matter volumes and white matter hyperintensities (WMHs). We identified four classes of depressive symptom trajectories: a “declining” class (n = 286, 7.3%) with initially high symptoms and subsequent decline, a class with consistently high symptoms (“steady high”; n = 264, 6.7%), a class with late increases in symptoms (“increasing”; n = 277, 7%), and a class with consistently low symptoms (“steady low”; n = 3117, 79.0%). The steady high and the increasing classes had poorer performance on all cognitive tests, while the declining class had poorer performance on the DSST, verbal fluency, and MoCA. Compared to the steady low symptom class, the steady high class had lower volumes in the entorhinal cortex (β: −180.80, 95% CI: −336.69 to −24.91) and the amygdala (β: −40.97, 95% CI: −74.09 to −7.85), the increasing class had more WMHs (β: 0.55, 95% CI: 0.22 to 0.89), and the declining class was not significantly different in any brain measures. Trajectories in depressive symptoms in young to mid-adulthood show distinct cognitive and brain phenotypes in midlife. Steady high depressive symptoms may represent a group that is at risk for dementia, whereas increasing symptoms in midlife may be associated with white matter damage.

show abstract

Section: Discussionmentioning

confidence: 99%

Trajectories in depressive symptoms and midlife brain health

Dintica,

Habes,

Schreiner

et al. 2024

Transl Psychiatry

View full text Add to dashboard Cite

show abstract

“…However, a study of 235 individuals from China (Yao et al, 2022) found that high scores on a neuroticism-related trait were associated with more WMH. The findings have also been mixed on the association between WMH and depression (Schuurmans et al, 2023), with a meta-analysis (N = 5876) reporting no association (odds ratio 1.12, 95% confidence interval 0.96-1.30, p = .14) (Wang et al, 2014). From this literature, it is clear that if there is any association between neuroticism and WMH, the association will likely have a small effect size and require a large sample to detect it reliably.…”

Section: Introductionmentioning

confidence: 99%

Neuroticism and white matter hyperintensities

Terracciano,

Cenatus,

Zhu

et al. 2023

Journal of Psychiatric Research

View full text Add to dashboard Cite

“…(antes dos 60 anos) ou "de início tardio (após os 60 anos)" implica em pressupor etiologias e vulnerabilidades diferentes. Especialmente a "depressão de início tardio" tem sido considerada uma manifestação prodrômica de doenças neurodegenerativas (como a Doença de Alzheimer) e/ou de alterações cerebrovasculares (SCHUURMANS, et al, 2023).…”

Section: Sintomas Depressivos Em Idososunclassified

Dependência para a realização de atividades instrumentais de vida diária e sintomatologia depressiva em pessoas idosas residentes na comunidade

Holovatino

View full text Add to dashboard Cite

10-Year trajectories of depressive symptoms and subsequent brain health in middle-aged adults

Cited by 4 publications

References 51 publications

Trajectories in depressive symptoms and midlife brain health

Trajectories in depressive symptoms and midlife brain health

Neuroticism and white matter hyperintensities

Dependência para a realização de atividades instrumentais de vida diária e sintomatologia depressiva em pessoas idosas residentes na comunidade

Contact Info

Product

Resources

About