10 Years of GWAS in intraocular pressure

Abstract

Intraocular pressure (IOP) is the only modifiable risk factor for glaucoma, the leading cause of irreversible blindness worldwide. In this review, we summarize the findings of genome-wide association studies (GWASs) of IOP published in the past 10 years and prior to December 2022. Over 190 genetic loci and candidate genes associated with IOP have been uncovered through GWASs, although most of these studies were conducted in subjects of European and Asian ancestries. We also discuss how these common variants have been used to derive polygenic risk scores for predicting IOP and glaucoma, and to infer causal relationship with other traits and conditions through Mendelian randomization. Additionally, we summarize the findings from a recent large-scale exome-wide association study (ExWAS) that identified rare variants associated with IOP in 40 novel genes, six of which are drug targets for clinical treatment or are being evaluated in clinical trials. Finally, we discuss the need for future genetic studies of IOP to include individuals from understudied populations, including Latinos and Africans, in order to fully characterize the genetic architecture of IOP.

High throughput functional profiling of genes at intraocular pressure loci reveals distinct networks for glaucoma

“…The most common glaucoma subtype is primary open-angle glaucoma (POAG) [ 1 , 2 ]. Elevated intraocular pressure (IOP) is the only known modifiable risk factor and plays a major role in the progression of POAG [ 3 ]. The circulatory system maintains IOP in the anterior segment of the eye [ 4 , 5 ].…”