2022
DOI: 10.1530/ec-21-0594
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100 YEARS OF VITAMIN D: Historical aspects of vitamin D

Abstract: Vitamin D has many physiological functions including upregulation of intestinal calcium and phosphate absorption, mobilization of bone resorption, renal reabsorption of calcium as well as actions on a variety of pleiotropic functions. It is believed that many of the hormonal effects of vitamin D involve a 1,25-dihydroxyvitamin D3-vitamin D receptor (VDR)-mediated transcriptional mechanism involving binding to the cellular chromatin and regulating hundreds of genes in many tissues. This comprehensive historical… Show more

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Cited by 52 publications
(45 citation statements)
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“…The role of vitamin D in health was first defined by its deficiency that results in rickets in children and osteomalacia in adults [ 1 ]. Vitamin D was first described in the early 1600s [ 2 ], and despite its name, it is a prohormone because humans do not obtain it only from their diet. Vitamin D is produced after exposure to ultraviolet B radiation (wavelength 290–315 nm) and can also be obtained from diet and supplements [ 3 ].…”
Section: Introductionmentioning
confidence: 99%
“…The role of vitamin D in health was first defined by its deficiency that results in rickets in children and osteomalacia in adults [ 1 ]. Vitamin D was first described in the early 1600s [ 2 ], and despite its name, it is a prohormone because humans do not obtain it only from their diet. Vitamin D is produced after exposure to ultraviolet B radiation (wavelength 290–315 nm) and can also be obtained from diet and supplements [ 3 ].…”
Section: Introductionmentioning
confidence: 99%
“…From 1969 to 1971, several groups, notably that of Egon Kodicek in Britain, identified 1,25(OH) 2 D 3 (calcitriol) from the kidney as the truly active metabolite of vitamin D [34][35][36][37]. The corresponding forms of vitamin D 2 were soon identified, as were other metabolites hydroxylated at C24, C26, and the various combinations of these hydroxylations [1,4]. This work established that both vitamins D 2 and D 3 are 25-hydroxylated in the liver, that 25OHD is the predominant metabolite in the circulation, and that the kidney then 1α-hydroxylates 25OHD to biologically active 1,25(OH) 2 D 2 or 1,25(OH) 2 D 3 .…”
Section: Vitamin D Biosynthesis and Its Disordersmentioning
confidence: 99%
“…All active vitamin D3s are mainly used clinically for the treatment of chronic renal insufficiency, parathyroidism, rickets, chondromalacia, and bone lesions caused by abnormal vitamin D3 metabolism. Calcitriol, for example, is 500–1000 times more active in calcium absorption, compared with 25-hydroxyvitamin D3 ( Figure 1 ) [ 8 , 9 ]. In addition, calcitriol is also used as an antitumor agent, fat emulsion, sebum secretion promoter, etc.…”
Section: Introductionmentioning
confidence: 99%