1001

Giralt, J.; Regadera, J; Romero, Jesús; Vergés, Ramona; Fuente, I. de la; Biete, Albert; Arenas, Meritxell; Cobo, Jesús; Guarner, Francisco

doi:10.1016/j.ijrobp.2006.07.265

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“…Another multi-centre, randomised, placebocontrolled nutrition trial reported that yogurt containing Lactobacillus casei DN-114 001 significantly improved the consistency of stool, without reducing the incidence of radiationinduced diarrhoea. 16 Conclusions from metaanalyses and systematic reviews should be interpreted with caution, because in these studies different types of probiotics are used to examine the effects on state of disease. 17 Literature searches identified three randomised, controlled for prevention and one for the treatment of radiation-induced diarrhoea.…”

Section: Introductionmentioning

confidence: 99%

Probiotics as prevention of radiation-induced diarrhoea

Timko

2010

J Radiother Pract

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Aim: To assess the efficacy of a probiotic preparation on the prevention of radiation-induced diarrhoea in cancer patients.Methods: Group of 42 radio-oncology patients who had undergone adjuvant post-operative radiation therapy (RT) after abdominal and pelvic cancer were randomised to receive either the probiotic preparation "5'' Strain Dophilus (twice per day; L-Group), or the preparation Hylak Tropfen Forte (40 drops, three times per day; H-Group). Supplementation started on the first day and lasted until the end of RT. Efficacy endpoints were the incidence and the severity of the radiation-induced diarrhoea. All patients received a paper form in which they recorded monitored parameters on a daily basis during RT. Results:The mean daily number of bowel movements during the whole period was 4.16 in the L-Group and 2.52 in the H-Group; 62.5% of patients in L-Group and 81% in H-Group had a mean daily number of bowel movements of 4/day. Abdominal pain was recorded in 25% of the patients in L-Group and 22% of the patients in H-Group. Blood in the bowel movement was found in one patient from H-Group (9 days). Of patients in L-Group, 27% required diphenoxylate treatment during pelvic radiotherapy, compared with 55% in H-Group. Of patients from L-Group, 9% required antibiotics administration, compared with 25% in H-Group.Conclusion: We concluded that the prophylactic probiotic therapy produced a highly favourable benefit/ risk ratio. Supplementation with the probiotic preparation is an easy and safe approach to protect cancer patients from the risk of radiation-induced diarrhoea and carry out improvement in their quality of life.

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Section: Introductionmentioning

confidence: 99%

Probiotics as prevention of radiation-induced diarrhoea

Timko

2010

J Radiother Pract

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1001

Cited by 1 publication

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Probiotics as prevention of radiation-induced diarrhoea

Probiotics as prevention of radiation-induced diarrhoea

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