1032 Treatment of maxillary sinus carcinomas: A comparison of the 1983 and 1997 AJCC staging systems

Le, Qiqi; Fu, Karen K.; Kaplan, Mustafa; Terris, David J.; Fee, Willard E.; Goffinet, Donald R.

doi:10.1016/s0360-3016(99)90258-4

Cited by 25 publications

(62 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Of the five patients with T1 or T2, N0 disease at presentation, four (80%) developed regional recurrence [8]. A retrospective series combining the Stanford and UCSF experiences of patients with maxillary sinus SCC, adenocarcinoma, undifferentiated carcinoma, and adenoid cystic carcinoma demonstrates that with an initial clinical N0 neck, the administration of elective neck irradiation decreases nodal relapse from a five-year actuarial rate of 20-0% [9]. As patients with nodal relapse in this study had poor survival, the authors recommend elective ipsilateral upper neck treatment for T3 or higher disease.…”

mentioning

confidence: 99%

Risk of lymph node metastasis and recommendations for elective nodal treatment in squamous cell carcinoma of the nasal cavity and maxillary sinus: a SEER analysis

et al. 2016

View full text Add to dashboard Cite

Results: Among 1283 patients, 182 (14.2%) had nodal involvement at presentation (4-27% by site and local extension). T-stage alone was associated with higher rates of nodal involvement in maxillary sinus SCC, while higher T-stage and size >2 cm were associated with higher rates of nodal involvement in nasal cavity SCC on multivariable analysis. Facial nodes and cervical nodes at levels 1 and 2 have the highest rates of involvement in T4a nasal cavity SCC, whereas nodal levels 1, 2, and/or 3 have the highest rates of involvement in T2 or higher maxillary sinus SCC when compared with a clinical reference standard. Conclusion:In this population-based study, there are high rates of initial nodal involvement when stratified by local extent determined by T-stage in nasal cavity SCC and maxillary sinus SCC, and independently by size in nasal cavity SCC. Involvement of the facial and nodal levels 1-3 varies depending on site and local extent of tumor involvement. These observations may help guide treatment decision making in the inclusion of and extent of elective nodal treatment fields.

show abstract

mentioning

confidence: 99%

Risk of lymph node metastasis and recommendations for elective nodal treatment in squamous cell carcinoma of the nasal cavity and maxillary sinus: a SEER analysis

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Local recurrence in comparison to squamous cell carcinoma remains the major cause of treatment failure in these tumors [8,17,18]. Pattern of failure in the present series revealed that 32.5% of patients failed at the primary site with isolated local failure (28.5%), the most common pattern of recurrence.…”

Section: Discussionmentioning

confidence: 50%

Clinical characteristics and outcome of non-squamous cell malignancies of the maxillary sinus

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Due to the location of SNCs relative to critical structures, escalating dose to a therapeutic level while limiting treatment-related toxicities has posed a challenge. Prior to the 3D-CRT era, patients were treated with conventional two-dimensional RT (2D-RT) and the prescription dose was typically limited to a median dose of 60-68 Gy (range, 39 Gy-77.2 Gy) [5,8,[11][12][13]18]. LC rates were poor, and serious ophthalmic toxicity occurred in up to 69 % of patients [11].…”

Section: Discussionmentioning

confidence: 99%

“…Retrospective studies have shown surgery followed by postoperative RT has Electronic supplementary material The online version of this article (doi:10.1007/s13566-015-0226-3) contains supplementary material, which is available to authorized users. superior 5-year local control (LC) rates, ranging from 40 to 79 % [2,[5][6][7] compared with definitive RT or CRT ranging from 20 to 64 % [2,5,[8][9][10][11][12][13][14][15][16][17][18]. However, due to the proximity of SNCs to critical structures such as the brain, optic nerves, orbital contents, and carotid artery, surgery for very locally advanced SNC is often a difficult, if not unattainable, option [3].…”

Section: Introductionmentioning

confidence: 99%

Function preservation and optimal outcomes—definitive chemoradiotherapy with multi-phase treatment planning for locally advanced sinonasal cancer

Burt¹,

Orlandi

Hunt

et al. 2015

J Radiat Oncol

View full text Add to dashboard Cite

Objectives The aim of this study is to review radiotherapy (RT) techniques and outcomes for definitive RT or chemoradiotherapy (CRT) for very locally advanced or unresectable sinonasal cancer (SNC) at a single institution. Methods Between 1998 and 2010, there were 11 patients with very locally advanced or unresectable SNCs treated with definitive CRT (8) and RT alone (3) at the University of Utah. CRT was given to stage IVA (5) and stage IVB (3) patients; RT alone was given to stage III (1) and stage IVA (2) patients. All patients were treated with intensity-modulated radiation therapy (IMRT). The median dose was 70.2 Gy (70-72.4 Gy). Most patients underwent two treatment planning phases in order to prevent critical structures from receiving a high dose due to tumor regression and weight loss. The most common chemotherapy was cisplatin 40 mg/m 2 given on a weekly basis for 6-7 cycles. A flexible nasal endoscopy with a biopsy was performed 3 months posttreatment to evaluate tumor response.Results With a median follow-up of 41 months (2-114), overall local control was seen in 8 out of 11 (72.7 %) patients. There was 1 (9.1 %) regional recurrence and 2 (18.2 %) distant metastasis. The definitive CRT or RT was well tolerated with only 2 patients experiencing a grade 3 late toxicity. Conclusion Definitive CRT or RT is feasible for very locally advanced or unresectable SNC. Local control is encouraging with acceptable treatment-related complications when treating with the described two-phase IMRT treatment technique.

show abstract

1032 Treatment of maxillary sinus carcinomas: A comparison of the 1983 and 1997 AJCC staging systems

Cited by 25 publications

References 3 publications

Risk of lymph node metastasis and recommendations for elective nodal treatment in squamous cell carcinoma of the nasal cavity and maxillary sinus: a SEER analysis

Risk of lymph node metastasis and recommendations for elective nodal treatment in squamous cell carcinoma of the nasal cavity and maxillary sinus: a SEER analysis

Clinical characteristics and outcome of non-squamous cell malignancies of the maxillary sinus

Function preservation and optimal outcomes—definitive chemoradiotherapy with multi-phase treatment planning for locally advanced sinonasal cancer

Contact Info

Product

Resources

About