1037 MRI does not accurately predict fat in evaluation for living donor liver transplantation

Tran, Tram T.; Colquhoun, Steven D.; Nissen, N.; Martin, P; Saouaf, Rola; Hwa, Lee Jin; Changsri, Chanikarn; Poordad, Fred; Geller, Stephen A.; Vierling, John M.

doi:10.1016/s0270-9139(03)81075-3

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“…Although imaging can provide estimates of hepatic ste-atosis, we have previously demonstrated a significant false-negative rate of MRI-derived hepatic fat estimates compared with that demonstrated on liver biopsy results. 21 We therefore continue to include this invasive test in our evaluation protocol. However, high-resolution MRI has otherwise markedly reduced the need for other invasive studies.…”

Section: Commentmentioning

confidence: 99%

Morbidity in Live Liver Donors

et al. 2005

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The true extent of morbidity among live liver donors remains poorly understood. In this unique and often high-profile area of surgery, the development of standards for defining and reporting complications would foster a better understanding of the incidence and magnitude of such adverse events (AEs). Design: Retrospective review of AEs among live liver donors. Setting: University-affiliated teaching hospital. Patients and Methods: Of 202 individuals undergoing evaluation for live liver donation, 42 (20.8%) proceeded to surgery. Thirty-four underwent a right lobectomy without the middle hepatic vein; 3, a left lateral segmentectomy. Any event causing a deviation from a patient's ideal course was considered an AE and subsequently classified according to a derived framework. Morbidity was defined as 1 or more AEs. Main Outcome Measures: Incidence, timing, type, severity, and impact of AEs. Results: No deaths or significant hepatic dysfunction occurred. In 5 (12%) of the 42 donors, the hepatectomy was aborted for anatomic reasons before parenchymal transection. Eight (22%) of the remaining 37 experienced 11 AEs, of which 10 completely resolved, whereas 1 AE (3%) resulted in a permanent disability (brachial plexopathy). The overall incidence of AEs was 0.30 per case. Ten (91%) of the 11 AEs presented within the first postoperative month. Conclusions: Most live liver donations are uncomplicated or do not lead to permanent consequence. The adoption of a standards-based classification framework for AEs in live liver donors would allow for an inclusive, consistent, and universally applicable method to collect, analyze, and report donor morbidity.

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Section: Commentmentioning

confidence: 99%