1044 Evaluation of a Novel Ultrasound Method for the Detection of Liver Fibrosis – Prospective Comparison With Transient Dynamic Elastography and Histology

Boozari, B.; Potthoff, Andrej; Mederacke, Ingmar; Hahn, Andreas; Reising, Ansgar; Rifai, K.; Wedemeyer, H.; Kubicka, Stefan; Manns, MP; Gebel, M

doi:10.1016/s0168-8278(10)61045-8

Cited by 11 publications

(13 citation statements)

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“…A retrospective review of histological findings of the liver was performed by two experienced pathologists blinded to the clinical patient data. The Metavir scoring system was used to assess liver fibrosis (F0, no fibrosis; F1, portal fibrosis without septa; F2, portal fibrosis with rare septa; F3, numerous septa and bridging fibrosis without cirrhosis; and F4, cirrhosis). On the basis of the degree of liver fibrosis, these 40 children were categorised into mild fibrosis group F0–F2 and moderate‐to‐severe fibrosis group F3–F4.…”

Section: Methodsmentioning

confidence: 99%

Differentiation between cystic biliary atresia and choledochal cyst: A retrospective analysis

Tang

Zhang

Liu

et al. 2017

J Paediatrics Child Health

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Section: Methodsmentioning

confidence: 99%

Differentiation between cystic biliary atresia and choledochal cyst: A retrospective analysis

Tang

Zhang

Liu

et al. 2017

J Paediatrics Child Health

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“…Liver fibrosis is the pathologic basis of many chronic liver diseases. Therefore, it is very important to provide an accurate assessment of the degree of liver fibrosis for diagnosis of the disease and in patients with chronic viral hepatitis to select appropriate antiviral therapy and predict the prognosis 1 , 2 . Real‐time elastography is a novel noninvasive ultrasound modality for measuring liver elasticity that has been recently applied to quantitiative assessment of liver fibrosis.…”

mentioning

confidence: 99%

Real-time Elastography for Diagnosis of Liver Fibrosis in Chronic Hepatitis B

Xie

Chen

Qiyong

et al. 2012

Journal of Ultrasound in Medicine

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Objectives The purpose of this study was to prospectively investigate the value of real‐time ultrasound elastography for diagnosis of liver fibrosis in patients with chronic hepatitis B and to correlate the elastographic findings with histologic stages of liver fibrosis and blood parameters. Methods Liver biopsies, blood testing, and real‐time elastography were performed in 71 patients with chronic viral hepatitis B and liver cirrhosis. The ratio of the elastic strain of liver tissue to that of muscle tissue was determined and correlated with the histologic fibrosis stages and laboratory examination results. Results There was a highly negative correlation between the elastic strain ratio and the histologic fibrosis stage (Spearman r = −0.702; P < .001). There was a high correlation observed between a decreasing elastic strain ratio and an increasing fibrosis stage. With substantial liver fibrosis (Scheuer score ≥S2) and cirrhosis (S4) as diagnostic criteria, the areas under the receiver operating characteristic curves (AUCs) of the elastic strain ratios were 0.863 and 0.797, respectively. The AUC for substantial fibrosis was higher than the AUC for the blood parameters used to diagnose substantial liver fibrosis. Elastic strain ratio cutoff values of 1.10 and 0.60 were identified as diagnostic of substantial fibrosis and cirrhosis, respectively, with sensitivities of 77.8% and 50.0%, respectively, and specificities of 80.0% and 96.7%. Conclusions Real‐time elastography is a new clinically promising and noninvasive method for quantitative assessment of liver fibrosis.

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“…In addition to classical imaging technologies, some proposals were reported to provide more specific ultrasonic tools for certain tissue characterizations or facilitate complementary diagnosis of human diseases [16,17,19–23,35]. They use a direct processing of the pulsed ultrasonic waveforms acquired from the analyzed medium, but searching other different tissue physical parameters such as elasticity [15,16,18,35] or temperature [19–23], being more sensible than the tissue densities with regards to some pathologic states.…”

Section: Systems Based On Pulsed Piezoelectric Transducers For Noninvmentioning

confidence: 99%

“…Certain similar high-resolution applications of mono-channel and array ultrasonic transducer systems in other medical areas have been preliminarily explored (some of them, very recently) to make possible internal measurements and non-invasive diagnosis of some human diseases [15–24]. They include the case of only one transducer actuating as an ultrasonic emitter and also performing echo detection.…”

Section: Introduction Piezoelectric Metrology and Working Hypothesesmentioning

confidence: 99%

“…The entire piezoelectric transduction system, so composed, has been shown to be an efficient tool to extract information about tissues in a non-invasive way to achieve different new medical objectives: (i) to provide data for the diagnosis of some viral or degenerative diseases like cirrhosis [15–18]; (ii) to estimate thermal distributions in tissues under hyperthermia cancer treatments by means of an analysis of the time echo-waveforms [19,21–23]. In the last case, the frequency spectral patterns can be successful processed [20,24], with promising further extensions, maybe making possible the detection of some tumors (such as in breast) in their early phases.…”

Section: Introduction Piezoelectric Metrology and Working Hypothesesmentioning

confidence: 99%

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Estimation of PSD Shifts for High-Resolution Metrology of Thickness Micro-Changes with Possible Applications in Vessel Walls and Biological Membrane Characterization

Ramos

Bazán

Negreira

et al. 2012

Sensors

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Achieving accurate measurements of inflammation levels in tissues or thickness changes in biological membranes (e.g., amniotic sac, parietal pleura) and thin biological walls (e.g., blood vessels) from outside the human body, is a promising research line in the medical area. It would provide a technical basis to study the options for early diagnosis of some serious diseases such as hypertension, atherosclerosis or tuberculosis. Nevertheless, achieving the aim of non-invasive measurement of those scarcely-accessible parameters on patient internal tissues, currently presents many difficulties. The use of high-frequency ultrasonic transducer systems appears to offer a possible solution. Previous studies using conventional ultrasonic imaging have shown this, but the spatial resolution was not sufficient so as to permit a thickness evaluation with clinical significance, which requires an accuracy of a few microns. In this paper a broadband ultrasonic technique, that was recently developed by the authors to address other non-invasive medical detection problems (by integrating a piezoelectric transducer into a spectral measuring system), is extended to our new objective; the aim is its application to the thickness measurement of sub-millimeter membranes or layers made of materials similar to some biological tissues (phantoms). The modeling and design rules of such a transducer system are described, and various methods of estimating overtones location in the power spectral density (PSD) are quantitatively assessed with transducer signals acquired using piezoelectric systems and also generated from a multi-echo model. Their effects on the potential resolution of the proposed thickness measuring tool, and their capability to provide accuracies around the micron are studied in detail. Comparisons are made with typical tools for extracting spatial parameters in laminar samples from echo-waveforms acquired with ultrasonic transducers. Results of this advanced measurement spectral tool are found to improve the performance of typical cross-correlation methods and provide reliable and high-resolution estimations.

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1044 Evaluation of a Novel Ultrasound Method for the Detection of Liver Fibrosis – Prospective Comparison With Transient Dynamic Elastography and Histology

Cited by 11 publications

References 0 publications

Differentiation between cystic biliary atresia and choledochal cyst: A retrospective analysis

Differentiation between cystic biliary atresia and choledochal cyst: A retrospective analysis

Real-time Elastography for Diagnosis of Liver Fibrosis in Chronic Hepatitis B

Estimation of PSD Shifts for High-Resolution Metrology of Thickness Micro-Changes with Possible Applications in Vessel Walls and Biological Membrane Characterization

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