1064 nm long‐pulsed Nd:YAG laser treatment of basal cell carcinoma

Ortiz, Arisa; Anderson, R. Rox; Avram, JD Mathew M.

doi:10.1002/lsm.22310

Cited by 38 publications

(59 citation statements)

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“…This study demonstrated a 92% histologic clearance rate (12 of 13 BCC tumors) after one treatment, while 100% clearance rates were achieved when stratified to those treated with fluences of 120 J/cm 2 (10 of 10 BCC tumors). Treatments were tolerated without any significant adverse events .…”

Section: Introductionmentioning

confidence: 99%

Outcomes of long‐pulsed 1064 nm Nd:YAG laser treatment of basal cell carcinoma: A retrospective review

2018

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Background and Objective Recent prospective trials have supported treatment of nonfacial BCC with long‐pulsed 1064 nm Nd:YAG laser based on short‐term histologic clearance rates. Studies have yet to identify the long‐term clinical clearance rates of this specific laser therapy for BCC. Study Design/Material and Methods This is a retrospective review of BCC treated with long‐pulsed 1064 nm Nd:YAG laser, which have been clinically monitored for at least 6 months, to assess for recurrence and cosmetic outcomes of the treated area. Results 16 BCC lesions (11 subjects) treated with 1064 nm Nd:YAG laser were enrolled. Our analysis revealed 100% clearance rate in all subjects (16 of 16 BCC) treated with long‐pulsed Nd:YAG laser based on mean follow‐up of 9 months (range 6–15 months). Minimal scarring and no long‐term adverse events were noted. Conclusions This study supports the use of 1064 nm Nd:YAG laser as a therapeutic modality for BCC based on the absence of clinical recurrence upon a mean follow‐up of 9 months. As studies progress, we are beginning to observe a potential role for laser as an alternative to patients who refuse surgery, have multiple co‐morbidities, or decline non‐surgical therapies. Laser treatment with 1064 nm Nd:YAG is an evolving, promising story that we continue to investigate to optimize parameters. Lasers Surg. Med. 51:34–39, 2019. © 2018 Wiley Periodicals, Inc.

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Section: Introductionmentioning

confidence: 99%

Outcomes of long‐pulsed 1064 nm Nd:YAG laser treatment of basal cell carcinoma: A retrospective review

2018

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“…The study demonstrated complete histologic clearance after 1 treatment in 92% of the BCC tumors, and at higher fluences, the study was able to demonstrate 100% histologic clearance after 1 treatment. 30 No significant adverse events were noted, including scarring.…”

Section: Laser Therapy For the Treatment Of Basal Cell Carcinomasmentioning

confidence: 94%

“…Lasers such as the long-pulsed 1,064 nm neodymium-doped yttrium aluminum garnet (Nd: YAG) and 755 nm Alexandrite lasers penetrate 50% to 75% deeper into the skin than the PDL. 13,26,28–30 Additionally, the conversion of oxyhemoglobin to methemoglobin after irradiation with PDL creates a second target chromophore for the Nd:YAG laser if PDL is used first followed by Nd:YAG. However, these lasers have a much lower absorption coefficient in blood than in PDL, requiring higher fluences and increasing the risk of adverse effects.…”

Section: Laser Therapy For the Treatment Of Basal Cell Carcinomasmentioning

confidence: 99%

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An Analysis of Laser Therapy for the Treatment of Nonmelanoma Skin Cancer

Soleymani

Abrouk

Kelly³

2017

Dermatol Surg

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BACKGROUND Skin cancer remains the most prevalent type of cancer in the United States, and its burden on the health care system remains substantial. Standard treatments such as cryosurgery, electrodessication and curettage, topical and photodynamic therapies, and surgical excision including Mohs micrographic surgery are not without inherent morbidity, including risk of bleeding, infection, and scar. OBJECTIVE Lasers may be an alternative for treatment of nonmelanoma skin cancer, and this paper reviews this therapeutic option. METHODS A comprehensive search in the Cochrane Library, MEDLINE, and PUBMED databases was performed to identify relevant literature investigating the role of laser therapy in the treatment of nonmelanoma skin cancer. RESULTS New literature regarding laser treatment of nonmelanoma skin cancer is emerging, demonstrating promising clinical outcomes. The greatest efficacy has been seen with vascular-selective and ablative lasers in the treatment of basal cell carcinomas. Some success has been reported for laser treatment of squamous cell carcinoma, but data are less convincing. In summary, laser therapy offers an alternative treatment option for nonmelanoma skin cancer; however, its clinical efficacy is variable and, at this time, remains less than currently accepted standards of care. CONCLUSION Further studies are needed to optimize parameters, determine maximum efficacy, and provide long-term follow-up.

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“…However, the occurrence of persistent dyspigmentation still limits the therapy success in terms of an excellent cosmetic outcome. Ortiz et al [27] put forward that the 1064-nm long-pulsed Nd:YAG laser could offer a safe alternative for treating BCC outside of the face with a prospective, non-randomized, open-label clinical trial. A larger study is required to confirm these preliminary results.…”

Section: Light and Lasers On Skin Cancermentioning

confidence: 98%

Light and lasers for vascular and skin diseases: From bench to clinic – An update

Wang

2016

Photonics &Amp; Lasers in Medicine

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1064 nm long‐pulsed Nd:YAG laser treatment of basal cell carcinoma

Abstract: The 1064 nm long-pulsed Nd:YAG laser may offer a safe alternative for treating BCC off the face. A larger study is highly warranted to confirm these preliminary results. Lasers Surg. Med. 47:106-110, 2015. © 2015 Wiley Periodicals, Inc.

Cited by 38 publications

References 18 publications

Outcomes of long‐pulsed 1064 nm Nd:YAG laser treatment of basal cell carcinoma: A retrospective review

Outcomes of long‐pulsed 1064 nm Nd:YAG laser treatment of basal cell carcinoma: A retrospective review

An Analysis of Laser Therapy for the Treatment of Nonmelanoma Skin Cancer

Light and lasers for vascular and skin diseases: From bench to clinic – An update

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