1078 Effects of alpha-blockers versus anticholinergics versus Seronoa repens in relieving double JJ ureteral stent-related symptoms: A prospective randomized comparative and controlled study

Khouni, H.; Dridi, Moez; Boulma, R.; Zouari, Mohamed; Ali, M. Ben; Khiari, Ramzi; Ghozzi, Samir; Raïs, N. Ben

doi:10.1016/s1569-9056(15)61066-1

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“…We followed the above search strategy and eventually retrieved 239 articles, 206 of which were excluded by eliminating duplicates and filtering titles and abstracts. Of the remaining 33 articles, 25 were excluded due to either not being found in the literature search or lacking valid data after reading the full articles, and eight studies were ultimately included to evaluate the efficacy and safety of tolterodine and α-adrenergic receptor blockers for the treatment of ureteral stent-related symptoms [8,[13][14][15][16][17][18][19]. The details, characteristics, and baseline summaries of the included studies are shown in Table 1.…”

Section: Study Selection Search Results and Characteristics Of The Tr...mentioning

confidence: 99%

Comparison of the efficacy and complications of tolterodine and α-adrenergic receptor blockers in improving ureteral stent-related symptoms: A systematic review and meta-analysis

Liu,

Mao

et al. 2024

PLoS ONE

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Objective We conducted a systematic evaluation of the therapeutic efficacy and complications of tolterodine and α-adrenergic receptor blockers in alleviating ureteral stent-related symptoms. Methods Until August 2023, we conducted a comprehensive literature search on PubMed, Embase, Web of Science, and Cochrane Library to identify randomized controlled trials evaluating the efficacy and complications of tolterodine and α-adrenergic receptor blockers in treating ureteral stent-related symptoms. Two reviewers independently screened studies and extracted data. The scores from various domains of the Ureteral Stent Symptom Questionnaire (USSQ) were summarized and compared, and statistical analysis was performed using RevMan 5.4.0 software. Results A total of 8 studies met the inclusion criteria for our analysis. These studies were conducted at different centers. All studies were randomized controlled trials, involving a total of 487 patients, with 244 patients receiving α-adrenergic receptor blockers and 243 patients receiving tolterodine. The results showed that tolterodine demonstrated significantly better improvement in body pain (MD, 1.56; 95% CI [0.46, 2.66]; p = 0.005) (MD, 0.46; 95% CI [0.12, 0.80]; p = 0.008) (MD, 3.21; 95% CI [1.89, 4.52]; p = 0.00001) among patients after ureteral stent placement compared to α-adrenergic receptor blockers at different time points. Additionally, at 4 weeks, tolterodine showed superior improvement in general health (MD, 0.15; 95% CI [0.03, 0.27]; p = 0.01) and urinary symptoms (MD, 1.62; 95% CI [0.59, 2.66]; p = 0.002) compared to α-adrenergic receptor blockers, while at 6 weeks, tolterodine showed better improvement in work performance (MD, -1.60; 95% CI [-2.73, -0.48]; p = 0.005) compared to α-adrenergic receptor blockers. Additionally, the incidence of dry mouth (RR, 4.21; 95% CI [1.38, 12.87]; p = 0.01) is higher with the use of tolterodine compared to α-adrenergic receptor blockers. However, there were no significant statistical differences between the two drugs in other outcomes. Conclusion This meta-analysis suggests that tolterodine is superior to α-adrenergic receptor blockers in improving physical pain symptoms after ureteral stent placement, while α-adrenergic receptor blockers are more effective than tolterodine in enhancing work performance. Additionally, the incidence of dry mouth is higher with the use of tolterodine compared to α-adrenergic receptor blockers. However, higher-quality randomized controlled trials are needed to further investigate this issue.

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Section: Study Selection Search Results and Characteristics Of The Tr...mentioning

confidence: 99%

Comparison of the efficacy and complications of tolterodine and α-adrenergic receptor blockers in improving ureteral stent-related symptoms: A systematic review and meta-analysis

Liu,

Mao

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

1078 Effects of alpha-blockers versus anticholinergics versus Seronoa repens in relieving double JJ ureteral stent-related symptoms: A prospective randomized comparative and controlled study

Cited by 1 publication

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Comparison of the efficacy and complications of tolterodine and α-adrenergic receptor blockers in improving ureteral stent-related symptoms: A systematic review and meta-analysis

Comparison of the efficacy and complications of tolterodine and α-adrenergic receptor blockers in improving ureteral stent-related symptoms: A systematic review and meta-analysis

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