1081 Microsomal Triglyceride Transfer Protein (Mtp) −493 G/T Polymorphism Is Associated With Fibrosis in Chronic Hepatitis C (Chc) Genotype 1 Infected Patients

Siqueira, Érika Rabelo Forte de; Oliveira, Carla Miguel de; Stefano, T.J.; Cavaleiro, Ana Mercedes; Fortes, Maria Angela Henriques Zanella; Muniz, Maria Tereza Cartaxo; Silva, Kléber Aparecido Da; Silva, F.S.; Correa-Gianella, Maria Lúcia; Pereira, Leila Maria Moreira Beltrão; Carrilho, F.

doi:10.1016/s0168-8278(10)61082-3

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Mtp Polymorphisms1

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2011

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“…A recent study by Siqueira et al demonstrated that the presence of the G allele of MTP -493 G/T, which is possibly associated with a lower MTP hepatic expression, protects CHC patients from steatosis. Additional studies in other populations are needed to further assess the role of this polymorphism as a modulator of hepatic steatosis in CHC [37]. Table 1 summarizes the polymorphisms discussed in this article.…”

Section: Mtp Polymorphismsmentioning

confidence: 99%

Microsomal triglyceride transfer protein and nonalcoholic fatty liver disease

Pereira

Stefano

Oliveira

2011

Expert Review of Gastroenterology & Hepatology

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Nonalcoholic fatty liver disease is currently one of the most common forms of liver disease, covering cases from simple steatosis without inflammation, to cases of steatohepatitis and fibrosis, and may lead to liver cirrhosis and hepatocellular carcinoma. The pathophysiology of nonalcoholic fatty liver disease is based on multiple events; changes in the secretion of lipoproteins can lead to steatosis. Liver lipid secretion is mediated by apoB100 and microsomal triglyceride transfer protein (MTP). The pharmacological suppression of MTP is suggested as a possible treatment for hyperlipidemia, although the upregulation of this protein can be a treatment for nonalcoholic steatohepatitis.

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Section: Mtp Polymorphismsmentioning

confidence: 99%