1097 Genetic polymorphisms of thymidylate synthase and DNA repair genes are associated with the toxicities of S-1 and cisplatin combination chemotherapy in metastatic or relapsed biliary tract cancer

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“…Rhee et al [1] from Korea investigated the association between toxicities to S-1 + cisplatin therapy and polymorphisms of genes relating to fluorouracil and cisplatin activity. They found that diarrhea and grade 3-4 anemia were more frequent in patients with a thymidylate synthase (TS) 3 0 -untranslated region (UTR) 6bp deletion homozygote.…”