10C-2 High Frequency Ultrasound Characterization of Blood Clotting Process: Results Obtained With Plasma and Whole Blood

Plag, Camille; Libgot, R.; Gruel, Yves; Patat, F.; Ossant, F.

doi:10.1109/ultsym.2007.226

Cited by 5 publications

(16 citation statements)

References 5 publications

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“…Recall that the addition of thrombin initiates coagulation. It was found that the amplitude of variation between the coagulating samples and the non-coagulating (without thrombin) samples was not large enough to be deemed statistically significant [69].…”

Section: Plasmamentioning

confidence: 98%

“…The studies that reported IAC values integrated across frequency ranges of 8-22 MHz [15] and 15-45 MHz [69]. For both ranges, an initial increase in the IAC was observed during phases that the authors attribute to RBC aggregation and the early stages of fibrin polymerization.…”

Section: Whole Bloodmentioning

confidence: 99%

“…where P is in g dL . The protein concentration was not recorded but was assumed to lie within the normal range (7±1 g dL −1 ) [69]. Experiments on coagulated plasma samples are less widely reported but it has been shown that the coagulation had no measurable impact on the acoustic velocity in the plasma samples [69].…”

Section: Blood Plasmamentioning

confidence: 99%

“…No other features were clearly identifiable from these experiments. While the IAC values are reported to have decreased as a result of clot formation [15,69], the relative attenuation coefficient was found to increase [45,90]. Although both metrics are meant to provide information on the sample's attenuation, this discrepancy could be due to the fact that the methods of evaluation are not directly analogous (IAC vs. relative attenuation coefficient) as well as the difference in frequency ranges considered.…”

Section: Whole Bloodmentioning

confidence: 99%

“…In this work, a HFUS system was developed to examine changes in the speed of sound, frequency dependant attenuation, and M-mode measurements during the coagulation process. These three parameters were compared, and for the first time, examined in a frequency range higher than 45 MHz [69]. Using a central frequency of 80 MHz achieved better backscatter strength and resolution for the M-mode images, and also produced measurements of changes in the frequency dependant attenuation at higher frequencies than have previously been observed in coagulating blood samples.…”

Section: Context Of Workmentioning

confidence: 99%

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Investigating the Kinetics of Blood Coagulation Using High-Frequency Ultrasound

Maher¹

2021

Preprint

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Blood circulation requires regulated clot formation and breakdown to prevent blood loss following an injury and to ensure that clots do not form and circulate within the vasculature. Known as hemostasis, this delicate balance between coagulant and anti-coagulant pathways can be disrupted by disease, medication, or trauma, and may lead to morbidity or mortality. Current in vitro hemostatic tests have shown promise as tools for diagnosis and risk assessment in certain disorders. However, these tests are limited in their ability to assess the complete hemostatic process or are restricted to studies of blood plasma. In this work, high frequency ultrasound is proposed as a method of assessing hemostasis in whole blood samples. A system was developed and experiments were performed by monitoring acoustic changes in mouse blood during coagulation. Blood cell motion and frequency dependant changes in ultrasound intensity were found to be sensitive to the kinetics of clot formation

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Section: Plasmamentioning

confidence: 98%

Section: Whole Bloodmentioning

confidence: 99%