10th international symposium on the synthesis and applications of isotopes and isotopically labelled compounds—production of isotopes, Session 14, Thursday, June 18, 2009

Positron emission tomography (PET) of slower biological processes calls for the use of longer lived positron emitting radioisotopes. Beyond radionuclide production considerations, practicality and rapidity of subsequent labeling chemistry further limits the selection of radioisotopes with potentially favorable nuclear properties. One additional limitation is the availability of PET radiotracers at the point-of-care with appropriate on-site production methodologies or robust radionuclide generator systems. The positron emitter (72)As (half-life 26 h) is generated via decay of (72)Se (half-life 8.5 d); this pair comprises and excellent generator system for clinical availability of a longer lived PET isotope. Many (72)Se/As generator systems have been introduced utilizing the rich interplay of Se(IV)/Se(VI) and As(III) /As(V) chemical behavior. This paper describes available generator concepts, and briefly outlines some current arsenic labeling methodologies for the introduction of radioarsenic into biomolecules.

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10th international symposium on the synthesis and applications of isotopes and isotopically labelled compounds—production of isotopes, Session 14, Thursday, June 18, 2009

Abstract: The theme of this session was the production of isotopes. Papers detailing the production of both stable and radioactive isotopes were detailed.

Cited by 3 publications

References 3 publications

Method for prediction of vapor pressure for isotopes and isotope-containing gases

Method for prediction of vapor pressure for isotopes and isotope-containing gases

Proton beam based production of positron emitters by exploiting the 27Al(p,x)22Na reaction

Radioarsenic from a Portable 72Se/72As Generator: A Current Perspective

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