11,12-EET suppressed LPS induced TF expression and thrombus formation by accelerating mRNA degradation rate via strengthening PI3K-Akt signaling pathway and inhibiting p38-TTP pathway

Luo, Lina; Yang, Yan; Fu, Menglu; Luo, Jing; Li, Wenhua; Tu, Lei; Dong, Ruolan

doi:10.1016/j.prostaglandins.2023.106740

Prostaglandins & Other Lipid Mediators

2023

DOI: 10.1016/j.prostaglandins.2023.106740

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11,12-EET suppressed LPS induced TF expression and thrombus formation by accelerating mRNA degradation rate via strengthening PI3K-Akt signaling pathway and inhibiting p38-TTP pathway

Lina Luo¹,

Yan Yang²,

Menglu Fu³

et al.

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2024

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Cited by 1 publication

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Oxylipins as therapeutic indicators of herbal medicines in cardiovascular diseases: a review

Li,

He,

Sun

et al. 2024

Front. Pharmacol.

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Globally, cardiovascular diseases (CVDs) remain the leading cause of death, and their prevention and treatment continue to face major challenges. Oxylipins, as novel circulating markers of cardiovascular disease, are crucial mediators linking cardiovascular risk factors such as inflammation and platelet activation, and they play an important role in unraveling cardiovascular pathogenesis and therapeutic mechanisms. Chinese herbal medicine plays an important role in the adjuvant treatment of cardiovascular diseases, which has predominantly focused on the key pathways of classic lipids, inflammation, and oxidative stress to elucidate the therapeutic mechanisms of cardiovascular diseases. However,The regulatory effect of traditional Chinese medicine on oxylipins in cardiovascular diseases remains largely unknown. With the increasing number of recent reports on the regulation of oxylipins by Chinese herbal medicine in cardiovascular diseases, it is necessary to comprehensively elucidate the regulatory role of Chinese herbal medicine in cardiovascular diseases from the perspective of oxylipins. This approach not only benefits further research on the therapeutic targets of Chinese herbal medicine, but also brings new perspectives to the treatment of cardiovascular diseases.

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Oxylipins as therapeutic indicators of herbal medicines in cardiovascular diseases: a review

Li,

He,

Sun

et al. 2024

Front. Pharmacol.

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show abstract

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11,12-EET suppressed LPS induced TF expression and thrombus formation by accelerating mRNA degradation rate via strengthening PI3K-Akt signaling pathway and inhibiting p38-TTP pathway

Cited by 1 publication

References 32 publications

Oxylipins as therapeutic indicators of herbal medicines in cardiovascular diseases: a review

Oxylipins as therapeutic indicators of herbal medicines in cardiovascular diseases: a review

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