11 -Desoxymisoprostol Tablets: Investigation of Tablet Stability

Yalkaev, A. G.; Kildiyarov, F. Kh.; Катаев, В. А.; Khalikov, R. A.; Федотова, А. А.

doi:10.19163/1994-9480-2017-3(63)-109-112

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“…Методика количественного определения ДМП в растворе -ВЭЖХ с УФ-детекцией [6]. Выбран обращено-фазный вариант хроматографии в изо-кратическом режиме.…”

Section: результаты и обсуждениеunclassified

Dissolution Test in Quality Assessment of Tablets Containing 11-Deoxymisoprostol

Федотова¹,

Георгиевич²,

Катаев³

et al. 2018

Kuban. nauсh. med. vestnik

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ФГБОУ ВО Башкирский государственный медицинский университет Министерства здравоохраненияРоссийской Федерации, ул. Пушкина, 96/98, Уфа, Россия, 450008 ABSTRACT Aim. Development of the dissolution test method of 11-deoxymisoprostol tablets. Materials and methods. The research was carried out on a "paddle apparatus". The media dissolution temperature is 37±0,5 degrees, the stirring rate is 50 rpm, the sampling time is 45 minutes, the dissolution media volume is 500 ml. The method of quantitative determination of 11-deoxymisoprostol in sample solution -HPLC with UV-detection, reverse phase chromatography. Chromatograph "Shimadzu Prominence LC-20" (Japan) with a matrix photodiode detector SPD-20, column Discovery C18 (5 μm; 150 mm x 4.6 mm), mobile phase: water-acetonitrile (50:50), isocratic elution, detection at a wavelength of 195 nm.Results. All tested tablet samples meet the requirements of the State Pharmacopoeia in terms of "Dissolution test". Conclusion.A dissolution test method of 11-deoxyimisoprostol tablets has been developed.

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Section: результаты и обсуждениеunclassified