111Indium leukocyte scanning in small-bowel Crohn's disease

Saverymuttu, S. H.; Peters, A. M.; Hodgson, H. J. F.; Chadwick, V. S.; Lavender, J. P.

doi:10.1007/bf01948113

Cited by 30 publications

(7 citation statements)

References 15 publications

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“…However, this is not the case for small bowel localization despite having scanned some patients by lateral and posterior views. Although Saverymuttu et al [7] and Fotherby et al [8] found a high sensitivity for small bowel Crohn's disease, they also reported similar problems concerning the lack of precision in determining the local ization and extent of the affected loops. This lack of precision can be attributed to movements of small bowel loops during the scanning time.…”

Section: Discussionmentioning

confidence: 92%

“…Saverymuttu et al [7] reported a series of 12 patients with Crohn's disease of the small intestine. In dium-1 11 scans were found to be as sensitive as oral barium small bowel examination.…”

Section: Discussionmentioning

confidence: 99%

“…Most of them are small series of patients, and the majority concern patients with colonic disease. The consensus from these studies is that there is a good to excellent agreement between local ization and extent of disease as shown by scans, with endoscopy and/or radiology in patients with colonic inflammatory bowel disease [3][4][5][6], However, this technique has provided some contradictory results in the evaluation of small bowel disease [7][8][9],…”

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confidence: 99%

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Value of Indium-111 Granulocyte Scintigraphy in the Assessment of Crohn’s Disease of the Small Intestine: Prospective Investigation

Crama-Bohbouth¹,

Arndt

Peña³

et al. 1988

Digestion

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The present study was undertaken to determine the value of indium-111 granulocyte scintigraphy in Crohn’s disease of the small bowel by comparing the results with those of radiology, endoscopy and surgery. Twenty-one patients with Crohn’s disease of the small bowel, 9 patients with Crohn’s disease of the colon, 1 patient with both localizations and 8 with ulcerative colitis were studied by indium-111 granulocyte scanning. Eighteen patients had evidence of active small intestinal disease based on clinical, radiologic, and/or endoscopic, and/or histopathological features. Thirteen of them had a true positive scan (sensitivity 72%), but accurate assessment of localization and extent of disease was often difficult. Five patients had a false negative scan and 4 a true negative. No false positive scans were found. The diagnostic accuracy was 77%. In contrast, from 18 patients with colonic disease, 16 had a true positive scan corresponding in localization and extent with standard investigations, 1 patient had a false negative scan (sensitivity 94%), and 1 a true negative (diagnostic accuracy 95%). This study also showed that 3–5 h scanning after injection of indium-111-labeled granulocytes is the optimal timing for this test. The patient’s acceptability of this procedure was definitely superior to radiology and endoscopy. In conclusion, this technique has a definite place in evaluating localization and extent of active colonic disease, but it does not replace good small bowel radiology and should not be recommended in the routine diagnostic workup of Crohn’s disease of the small intestine.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Value of Indium-111 Granulocyte Scintigraphy in the Assessment of Crohn’s Disease of the Small Intestine: Prospective Investigation

Crama-Bohbouth¹,

Arndt

Peña³

et al. 1988

Digestion

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“…Negative scintigrams occur in the irritable bowel syndrome (Saverymuttu et al, 1983a and1983c) and a recent study (Saverymuttu et al, 1985) shows that scintigraphy identifies those patients presenting with chronic diarrhoea who have CIBD.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have shown that scintigraphy can correlate well with radiology in indicating the site and extent of inflammation affecting the colon (Saverymuttu et al, 1982;Stein et al, 1983a). In ileal disease, although scintigraphy may indicate the presence of inflammation, it is not always accurate in defining its extent (Saverymuttu et al, 1983a). In addition, scintigraphy is non-invasive and may identify abscesses (Saverymuttu et al, 1983b;Ambrose et al, 1983) and indicate the severity of disease affecting the colon either directly from the scintigram (Saverymuttu et al, 1984) or from measurement of faecal indium-l11 excretion (Saverymuttu et al, 1983c).…”

Section: Introductionmentioning

confidence: 99%

Indium-111 leucocyte scintigraphy in the investigation and management of inflammatory bowel disease

Fotherby

Wraight

Garforth

et al. 1986

Postgraduate Medical Journal

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Summary:The results of indium-111 tropolonate leucocyte scintigraphy in 105 patients with known inflammatory bowel disease are reviewed. Scintigraphy is as sensitive as radiology in detecting and assessing the extent of active colonic disease, and probably more sensitive in assessing small bowel disease. In a further 40 patients scintigraphy was successfully used as a screening test to identify, or exclude, bowel inflammation in patients with gastrointestinal symptoms. Scintigraphy has advantages over barium studies, being safe, non-invasive, more sensitive than small bowel radiology and giving additional information such as the bowel identification of intra-abdominal abscesses. The time required to label the leucocytes (about 2 hours) and the higher unit cost, unless many scintigrams are performed, are disadvantages.

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Recent Advances in Gastrointestinal Radiology

Stevenson

1986

Modern Concepts in Gastroenterology

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111Indium leukocyte scanning in small-bowel Crohn's disease

Cited by 30 publications

References 15 publications

Value of Indium-111 Granulocyte Scintigraphy in the Assessment of Crohn’s Disease of the Small Intestine: Prospective Investigation

Value of Indium-111 Granulocyte Scintigraphy in the Assessment of Crohn’s Disease of the Small Intestine: Prospective Investigation

Indium-111 leucocyte scintigraphy in the investigation and management of inflammatory bowel disease

Recent Advances in Gastrointestinal Radiology

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