113 Complexity of the immune response to a protease and implications for the safety assessment of novel enzyme-containing products

Accumulation and Identification of Angiotensin-Converting Enzyme Inhibitory Peptides from Wheat Germ

“…Currently, the method of preparing antihypertensive peptides by adding outer proteases to hydrolyze protein has been commonly used, which has the advantage of conveniently controlling the concentration of enzyme and substrate. Nevertheless, there may be some insecurity factors including microbial toxin because the majority of industrial proteases is derived from microorganism by fermentation . The endogenous proteases, which are derived from plant tissues, can hydrolyze insoluble stored proteins into soluble protein, peptides, and amino acids under appropriate reaction conditions.…”

“…Nevertheless, there may be some insecurity factors including microbial toxin because the majority of industrial proteases is derived from microorganism by fermentation. 20 The endogenous proteases, which are derived from plant tissues, can hydrolyze insoluble stored proteins into soluble protein, peptides, and amino acids under appropriate reaction conditions. In this process, some bioactive peptides were generated.…”