1130 – Transferable Iga-Reactive Microbiota Stratify Clinical Response to Fmt for Ulcerative Colitis

Gogokhia, Lasha; Crawford, Carl V.; Lima, Svetlana; Viladomiu, Monica; Jacob, Vinita; Scherl, Ellen; Rosenthal, Melissa; Brown, S.; Hambor, John E.; Longman, Randy S.

doi:10.1016/s0016-5085(19)37397-4

Cited by 1 publication

(2 citation statements)

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“…A number of differences were observed between responders and non-responders after FMT ( Table 4 ). Several bacteria showed a relatively consistent trend in separate studies, in which the increased microorganisms included the phyla Bacteroidetes ( 22 , 36 ), the family Lachnospiraceae ( 14 , 27 , 30 , 31 , 34 ), and the genera Collinsella ( 33 , 34 ), Bacteroides ( 14 , 15 ), Blautia ( 14 , 34 ), Faecalibacterium ( 14 , 15 , 33 , 34 ), Eubacterium ( 11 , 15 ), Clostridium clusters IV ( 36 , 42 ), Roseburia ( 14 , 20 , 27 ), and Ruminococcus ( 11 , 30 , 42 ). In contrast, the relative abundance of the genera Enterococcu s ( 14 , 37 ), Lactobacillus ( 14 , 34 ), Veillonella ( 10 , 37 ), and Sutterella ( 14 , 42 ) was reported to decrease in responders.…”

Section: Resultsmentioning

confidence: 78%

“…In contrast, the relative abundance of the genera Enterococcu s ( 14 , 37 ), Lactobacillus ( 14 , 34 ), Veillonella ( 10 , 37 ), and Sutterella ( 14 , 42 ) was reported to decrease in responders. For the species level, responders had an increased abundance of the species Ruminococcus bromii ( 10 , 16 ), Eubacterium hallii ( 10 , 37 ), Eubacterium ventriosum ( 19 , 37 ), and F. prausnitzii ( 17 , 27 , 32 ), and reduced abundance of species Bacteroides vulgatus ( 19 , 37 ) , E. coli ( 18 , 30 , 37 ) , Escherichia-Shigella ( 29 , 30 ), and Sutterella wadsworthensis ( 10 , 37 ). A few of bacteria showed an opposite changing trend in their abundance, including the family Ruminococcaceae ( 33 , 34 ) and Christensenellaceae ( 30 , 34 ), the genus Escherichia ( 10 , 15 ), and the species Bacteroides ovatus ( 16 , 17 , 19 , 37 ) and Ruminococcus gnavus ( 16 , 37 ).…”

Section: Resultsmentioning

confidence: 99%

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Features of Gut Microbiome Associated With Responses to Fecal Microbiota Transplantation for Inflammatory Bowel Disease: A Systematic Review

Zhang

Guo²,

Duan³

2022

Front. Med.

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Fecal microbiota transplantation (FMT) has been seen as a novel treatment for inflammatory bowel disease (IBD). The results on microbial alterations and their relationship to treatment efficacy are varied among studies. We performed a systematic review to explore the association between microbial features and therapy outcomes. We searched PubMed, Web of Science, Embase, and Cochrane Library databases from inception to November 2020. Studies that investigated the efficacy of FMT and baseline microbial features or dynamic alteration of the microbiome during FMT were included. The methodological quality of the included cohort studies and randomized controlled trials (RCTs) was assessed using the Newcastle–Ottawa Scale (NOS) and the Cochrane risk of bias tool, respectively. A total of 30 studies were included in the analysis. Compared to non-responders, the microbial structure of patients who responded to FMT had a higher similarity to that of their donors after FMT. Donors of responders (R-d) and non-responders (NR-d) had different microbial taxa, but the results were inconsistent. After FMT, several beneficial short-chain fatty acids- (SCFA-) producing taxa, such as Faecalibacterium, Eubacterium, Roseburia, and species belonging to them, were enriched in responders, while pathogenic bacteria (Escherichia coli and Escherichia-Shigella) belonging to the phylum Proteobacteria were decreased. Alterations of microbial functional genes and metabolites were also observed. In conclusion, the response to FMT was associated with the gut microbiota and their metabolites. The pre-FMT microbial features of recipients, the comparison of pre- and post-FMT microbiota, and the relationship between recipients and donors at baseline should be further investigated using uniform and standardized methods.

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