1136-80 Postconditioning by repetitive I/R cycles subsequent to myocardial ischemia protects the rat heart from infarction and is dependent on the activation of PI 3-kinase and mTOR

Weinbrenner, Christof; Reußner, Claudia; Sütterlin, Stefan; Sárváry, László; Strasser, Ruth H.

doi:10.1016/s0735-1097(04)91243-0

Cited by 1 publication

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“…33) Studies have revealed the implication of opioid receptor activation in the cardioprotective eŠect of remote preconditioning of heart. 8,16) Hence, it may also be suggested that neuroprotective eŠect of remote mesenteric ischaemic preconditioning in the present study is due to the release of endogenous opioids and consequent activation of opioid receptors, which is further supported by our study with naloxone (a selective opioid receptor antagonist) that attenuated the protective eŠect of mesenteric preconditioning on ischaemiareperfusion induced cerebral injury. Calcitonin gene related peptide (CGRP) is a highly potent vasodilator in the vasculature of brain and is released in the nerve terminals present in the intestine.…”

Section: Discussionsupporting

confidence: 77%

“…6) Remote ischaemic preconditioning refers to protective eŠect of brief episodes of ischaemia in one region, which provides protection to severe ischaemia in other distant organ. 7) Such a protective eŠect of remote ischaemic preconditioning has been produced in myocardium by prior occlusion and reperfusion of infrarenal aorta, 8) mesenteric, 9) renal 10) or femoral artery. 11) Recently we have observed that remote ischaemic preconditioning by mesenteric artery occlusion-reperfusion reverses the ischaemic injury in brain.…”

Section: Introductionmentioning

confidence: 99%

“…15) Besides, activation of opioid receptors has also been implicated in cardioprotective eŠect of remote ischaemic preconditioning. 8,16) Calcitonin gene related peptide (CGRP) is one of the most potent dilator stimuli in the cerebral circulation. 17) Moreover, cardioprotective eŠect of remote preconditioning of heart has been ascribed to the increase in the concentration of plasma CGRP levels secondary to the remote ischaemia and the consequent CGRP receptor activation.…”

Section: Introductionmentioning

confidence: 99%

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Possible Involvement of Insulin, Endogenous Opioids and Calcitonin Gene Related Peptide in Remote Ischaemic Preconditioning of Brain

2007

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The present study has been designed to investigate the role of insulin, endogenous opioids and calcitonin gene related peptide (CGRP) on remote mesenteric ischaemic preconditioning induced reversal of global cerebral ischaemiareperfusion injury in mice. Bilateral carotid artery occlusion of 10 min followed by reperfusion for 24 hour was employed in present study to produce ischaemia and reperfusion induced cerebral injury in mice. Cerebral infarct size was measured using triphenyltetrazolium chloride staining. Short-term memory was evaluated using elevated plus maze. Inclined beam walking and resistance to lateral push response, tests were employed to assess motor incoordination. Bilateral carotid artery occlusion followed by reperfusion produced cerebral infarction and impaired short-term memory, motor co-ordination and lateral push response. A preceding episode of mesenteric artery occlusion for 15 min and reperfusion of 15 min (remote mesenteric ischaemic preconditioning) prevented markedly, ischaemia-reperfusion-induced cerebral injury measured in terms of infarct size, loss of short-term memory, motor coordination and lateral push response. Anti-insulin serum, naloxone (an opioid receptor antagonist) and a-CGRP (8 37) (a selective CGRP receptor blocker) attenuated the neuroprotective eŠect of remote mesenteric ischaemic preconditioning. It may be concluded that neuroprotective eŠect of remote mesenteric ischaemic preconditioning probably is mediated through insulin, endogenous opioids and CGRP released as a consequence of mesenteric ischaemia and reperfusion in mice.

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Section: Discussionsupporting

confidence: 77%