11C-methionine PET as a prognostic marker in patients with glioma: comparison with 18F-FDG PET

Abstract

Compared with FDG PET in glioma, MET PET was an independent significant prognostic factor and MET uptake was correlated with cellular proliferation. MET PET may be a useful biological prognostic marker in glioma patients.

Relationship between [ 14 C]MeAIB uptake and amino acid transporter family gene expression levels or proliferative activity in a pilot study in human carcinoma cells: Comparison with [ 3 H]methionine uptake

“…Therefore, natural or artificial amino acid analogs have been widely studied clinically as potential post-FDG radiopharmaceuticals for PET imaging; One of the most important radiolabeled amino acids in this regard is [S-methyl-11 C]-L-methionine ([ 11 C]MET) [6,7]. Since both amino acid transport and protein synthesis rates are enhanced in tumors, [ 11 [8,9].…”

11C‐methionine uptake and intraoperative 5‐aminolevulinic acid‐induced fluorescence as separate index markers of cell density in glioma

“…These 2 novel approaches offer benefits for glioma resection, and combining these approaches in glioma surgery is rational. However, limited information is available regarding the relationship between 11 C-methionine uptake and 5-ALA-induced PPIX accumulation in glioma tissues. Moreover, only limited information has been reported on the tumor characteristics correlating with each of these parameters.…”

“…17 Image-guided resection with PET images has thus become important in cytoreduction surgery for glioma. In particular, increasing evidence suggests the utility of 11 C-methionine PET for the purpose of delineating the tumor invasion area. 5 On the other hand, fluorescence-guided resection using 5-aminolevulinic acid (5-ALA) has been developed to achieve the same goal.…”

“…Positron emission tomography (PET) with administration 18 F-FDG), 11 C-methionine, 11 C-choline, or 18 F-fluoroethyl-tyrosine ( 18 F-FET) has been applied to the delineation of tumor extension, prediction of prognosis, monitoring of therapeutic effects, and diagnosis of tumor grade, although the clinical utility for these purposes remains controversial. 5,[7][8][9][10][11][12][13][14][15][16] To take advantage of PET, images from this modality have been integrated into neuronavigation for image-guided resection of gliomas. In fact, a previous report showed that complete resection of areas showing increased PET tracer uptake significantly prolonged survival among patients with high-grade glioma, whereas total resection based on MRI contrast enhancement did not.…”

Contributions of biological tumor parameters to the incorporation rate of l-[methyl-11C] methionine into astrocytomas and oligodendrogliomas

“…In one biochemical analysis, 11 C-methionine uptake was reported to reflect both protein synthesis in tumor cells and amino acid transport in tumor endothelial cells [16]. Several reports have suggested that 11 C-methionine uptake measured with PET reflects the proliferative index of gliomas [17,18] and microvessel density of tumor tissue, putative markers of protein synthesis and amino acid transport through microvessels, respectively [19].…”