[11C]-PK11195 PET: Quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease?

Bartels, Anna L.; Willemsen, Antonius; Doorduin, Janine; Vries, de Erik; Dierckx, Rudi; Leenders, Klaus L.

doi:10.1016/j.parkreldis.2009.05.005

Cited by 162 publications

(113 citation statements)

References 12 publications

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“…Whereas results of previous PET studies using 11 C-PK11195 in Parkinson's disease showed increased binding in the midbrain 35 and different frontal and temporal cortical regions, 36 other reports did not identify major differences between binding in Parkinson's disease and controls. 37 Conversely, more consistent increases in 11 C-PK11195 binding have been reported in multiple systems atrophy, 38 progressive supranuclear palsy, 39 corticobasal degeneration, 40 and Huntington's disease. 41 Reasons for such variability could include limitations inherent to this particular tracer, such as high non-specific binding, low brainpenetration, high plasma-protein-binding, and difficult preparation.…”

Section: Neuroinflammationmentioning

confidence: 92%

Imaging insights into basal ganglia function, Parkinson's disease, and dystonia

Stoessl¹,

Lehericy²,

Strafella³

2014

The Lancet

141

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Recent advances in structural and functional imaging have greatly improved our ability to assess normal functions of the basal ganglia, diagnose parkinsonian syndromes, understand the pathophysiology of parkinsonism and other movement disorders, and detect and monitor disease progression. Radionuclide imaging is the best way to detect and monitor dopamine deficiency, and will probably continue to be the best biomarker for assessment of the effects of disease-modifying therapies. However, advances in magnetic resonance enable the separation of patients with Parkinson's disease from healthy controls, and show great promise for differentiation between Parkinson's disease and other akinetic-rigid syndromes. Radionuclide imaging is useful to show the dopaminergic basis for both motor and behavioural complications of Parkinson's disease and its treatment, and alterations in non-dopaminergic systems. Both PET and MRI can be used to study patterns of functional connectivity in the brain, which is disrupted in Parkinson's disease and in association with its complications, and in other basal-ganglia disorders such as dystonia, in which an anatomical substrate is not otherwise apparent. Functional imaging is increasingly used to assess underlying pathological processes such as neuroinflammation and abnormal protein Correspondence to: Prof A J Stoessl,

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Section: Neuroinflammationmentioning

confidence: 92%

Imaging insights into basal ganglia function, Parkinson's disease, and dystonia

Stoessl¹,

Lehericy²,

Strafella³

2014

The Lancet

141

View full text Add to dashboard Cite

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“…Recent evidence suggests that neurodegenerative disorders such as Alzheimer's and Parkinson's diseases (and interestingly also schizophrenia), are also associated with chronic neuroinflammation [100,101]. Chronic neurodegeneration is associated with morphological and cell surface marker evidence of selective activation of microglial cells, but only minimal pro-inflammatory cytokine synthesis [102].…”

Section: Neurodegeneration As a Cause Of Primingmentioning

confidence: 99%

“…Activation of microglia is associated with expression of peripheral benzodiazepine receptor on mitochondria. This receptor is selectively expressed in the mitochondrial walls of activated microglia [100,101], and thus positron-emission tomography scanning with 11 C-PK11195 can provide a quantitative assay of cerebral inflammation. Other positron-emission tomography modalities that may provide important information include functional methods for assessing cerebral glucose metabolism (e.g.…”

Section: The Futurementioning

confidence: 99%

A review of postoperative cognitive dysfunction and neuroinflammation associated with cardiac surgery and anaesthesia

Harten¹,

2012

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SummaryPostoperative cognitive dysfunction is receiving increasing attention, particularly as it mainly affects the (growing) elderly population. Until recently, cognitive deficits after cardiac surgery were thought to be caused by physiological disturbances associated with the cardiopulmonary bypass technique. Although the technique of 'off-pump' coronary revascularisation may potentially be associated with improved outcome, long-term follow-up studies have failed to demonstrate a significant reduction in the incidence of postoperative cognitive dysfunction. The focus of research is thus shifting from cardiopulmonary bypass to other factors common to both techniques, such as surgery, anaesthesia and patient-related predisposing factors. Priming of the immune system by ageing and atherosclerosis may result in an exaggerated systemic and cerebral inflammatory response to cardiac surgery and anaesthesia, causing neuronal loss or dysfunction resulting in cognitive dysfunction. We briefly discuss the evidence for cardiopulmonary bypass-related neuronal injuries in adult cardiac surgery patients, and review the evidence that immune priming is a key factor in the pathogenesis of cognitive dysfunction after cardiac surgery.

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“…Pathologic changes in the PD brain are closely related to microglial activation induced inflammation, which accelerates dopamine (DA)-producing neuron death. Interestingly, positron emission tomography (PET) studies have shown noticeable microglial activation in the SN, putamen and subcortical and cortical areas of the PD brain [10,11].…”

Section: Relations Between Microglial Activation and Neuronal Cell Dementioning

confidence: 99%

Ligands of Receptor for Advanced Glycation End-Products Produced by Activated Microglia are Critical in Neurodegenerative Diseases

Son¹,

Oh²,

Lee³

et al. 2017

J Alzheimers Dis Parkinsonism

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[11C]-PK11195 PET: Quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease?

Cited by 162 publications

References 12 publications

Imaging insights into basal ganglia function, Parkinson's disease, and dystonia

Imaging insights into basal ganglia function, Parkinson's disease, and dystonia

A review of postoperative cognitive dysfunction and neuroinflammation associated with cardiac surgery and anaesthesia

Ligands of Receptor for Advanced Glycation End-Products Produced by Activated Microglia are Critical in Neurodegenerative Diseases

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