11th Annual International Symposium in Obesity: ‘Obesity in a modern world: when pleasure meets homeostasis’

Richard, Denis; Boisvert, P

doi:10.1038/ijo.2009.63

Cited by 2 publications

(2 citation statements)

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“…Obesity is strongly associated with both type 2 diabetes mellitus (T2DM) and hypertension, a combination that has become a major public health problem because of its epidemic proportions worldwide [1]. The renin-angiotensin system (RAS) is overexpressed when associated with obesity and its comorbidities and has emerged as an important target for pharmacological treatment [2,3].…”

Section: Introductionmentioning

confidence: 99%

Renin-Angiotensin System Blockers Protect Pancreatic Islets against Diet-Induced Obesity and Insulin Resistance in Mice

et al. 2013

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BackgroundThe associations between obesity, hypertension and diabetes are well established, and the renin-angiotensin system (RAS) may provide a link among them. The effect of RAS inhibition on type 2 diabetes is still unclear; however, RAS seems to play an important role in the regulation of the pancreas and glucose intolerance of mice fed high-fat (HF) diet.MethodsC57BL/6 mice fed a HF diet (8 weeks) were treated with aliskiren (50 mg/kg/day), enalapril (30 mg/kg/day) or losartan (10 mg/kg/day) for 6 weeks, and the protective effects were extensively compared among groups by morphometry, stereological tools, immunostaining, Western blotting and hormonal analysis.ResultsAll RAS inhibitors significantly attenuated the increased blood pressure in mice fed a HF diet. Treatment with enalapril, but not aliskiren or losartan, significantly attenuated body mass (BM) gain, glucose intolerance and insulin resistance, improved the alpha and beta cell mass and prevented the reduction of plasma adiponectin. Furthermore, enalapril treatment improved the protein expression of the pancreatic islet Pdx1, GLUT2, ACE2 and Mas receptors. Losartan treatment showed the greatest AT2R expression.ConclusionOur findings indicate that ACE inhibition with enalapril attenuated several of the deleterious effects of the HF diet. In summary, enalapril appears to be responsible for the normalization of islet morphology and function, of alpha and beta cell mass and of Pdx1 and GLUT2 expression. These protective effects of enalapril were attributed, primarily, to the reduction in body mass gain and food intake and the enhancement of the ACE2/Ang (1-7) /Mas receptor axis and adiponectin levels.

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Section: Introductionmentioning

confidence: 99%

Renin-Angiotensin System Blockers Protect Pancreatic Islets against Diet-Induced Obesity and Insulin Resistance in Mice

et al. 2013

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“…In 2008, for the 11th annual symposium series, the Research Chair in Obesity organized a program dedicated to the 'reward system' which was called 'Obesity in a modern world: when pleasure meets homeostasis'. 10 In 2009, an advisory committee to the Chair recommended, 10 years after the symposium on 'Recent advances in adipose tissue biology', to revisit this theme by organizing for the 12th annual symposium series, a program dedicated to the 'Brown adipose tissue'. 11 In October 2010, the 13th symposium focused on how 'Bariatric/ metabolic surgery influences the energy balance regulation'.…”

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confidence: 99%

The 14th annual international symposium in obesity—high-fat feeding: worse than once thought

Richard

Boisvert²

2012

Int J Obes Supp

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11th Annual International Symposium in Obesity: ‘Obesity in a modern world: when pleasure meets homeostasis’

Cited by 2 publications

References 10 publications

Renin-Angiotensin System Blockers Protect Pancreatic Islets against Diet-Induced Obesity and Insulin Resistance in Mice

Renin-Angiotensin System Blockers Protect Pancreatic Islets against Diet-Induced Obesity and Insulin Resistance in Mice

The 14th annual international symposium in obesity—high-fat feeding: worse than once thought

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