2023
DOI: 10.1152/ajplung.00009.2022
|View full text |Cite
|
Sign up to set email alerts
|

11β-HSD1 determines the extent of muscle atrophy in a model of acute exacerbation of COPD

Abstract: Muscle atrophy is an extra-pulmonary complication of acute exacerbations (AE) in chronic obstructive pulmonary disease (COPD). The endogenous production and therapeutic application of glucocorticoids (GCs) have been implicated as drivers of muscle loss in AE-COPD. The enzyme 11 beta-hydroxysteroid dehydrogenase 1 (11β-HSD1) activates GCs and contributes towards GC-induced muscle wasting. To explore the potential of 11βHSD1 inhibition to prevent muscle wasting here, the objective of this study was to ascertain … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2023
2023
2023
2023

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
(1 citation statement)
references
References 66 publications
0
1
0
Order By: Relevance
“…The regulation of muscle atrophy induced by chronic GC exposure appears to be associated with the activity of enzyme 11-beta hydroxysteroid dehydrogenase 1 (11β-HSD1), which converts cortisone to cortisol. This enzyme is also involved in the development of GC-induced insulin resistance, a factor possibly contributing to muscle atrophy [ 109 , 110 ]. The effect of GCs on fast- and slow-twitch skeletal muscles is not similar: fast-twitch skeletal muscles are more susceptible to the negative impact of GCs ( Figure 3 ).…”
Section: Steroids Obesity and Skeletal Musclesmentioning
confidence: 99%
“…The regulation of muscle atrophy induced by chronic GC exposure appears to be associated with the activity of enzyme 11-beta hydroxysteroid dehydrogenase 1 (11β-HSD1), which converts cortisone to cortisol. This enzyme is also involved in the development of GC-induced insulin resistance, a factor possibly contributing to muscle atrophy [ 109 , 110 ]. The effect of GCs on fast- and slow-twitch skeletal muscles is not similar: fast-twitch skeletal muscles are more susceptible to the negative impact of GCs ( Figure 3 ).…”
Section: Steroids Obesity and Skeletal Musclesmentioning
confidence: 99%