[12]aneN3-Conjugated AIEgens with two-photon imaging properties for synergistic gene/photodynamic therapy in vitro and in vivo

Liu, Xuying; Yang, Jingbo; Wu, Chengyan; Tang, Quan; Lu, Zhong‐Lin; Liu, Lin

doi:10.1039/d1tb02352g

Cited by 13 publications

(21 citation statements)

References 51 publications

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“…2C). 22,23 These results suggested that the excellent nucleic acid condensation capability of CNN1-D–CNN3-D was suitable for efficient gene delivery as non-viral gene vector.…”

Section: Resultsmentioning

confidence: 92%

“…18,19 We have developed a series of macrocyclic polyamine [12]aneN 3 -derived functional non-viral gene vectors and demonstrated their performance in improving the gene transfection efficiency. [20][21][22][23][24][25] However, cancer therapy based on one single strategy is not always effective, combining multiple therapeutic strategies with synergistic effects may be a promising approach for cancer treatment. 26 Recently, there have been notable advances in cancer therapy through the co-delivery of anticancer drugs and genes, which have achieved synergistic therapeutic effects.…”

Section: Introductionmentioning

confidence: 99%

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[12]aneN₃-modified camptothecin and PEGylated AIEgens co-assembly into core–shell nanoparticles with ROS/NTR dual-response for enhanced cancer therapy

Sun,

Liang,

Gao

et al. 2023

J. Mater. Chem. B

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“…2C). 22,23 These results suggested that the excellent nucleic acid condensation capability of CNN1-D–CNN3-D was suitable for efficient gene delivery as non-viral gene vector.…”

Section: Resultsmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

[12]aneN₃-modified camptothecin and PEGylated AIEgens co-assembly into core–shell nanoparticles with ROS/NTR dual-response for enhanced cancer therapy

Sun,

Liang,

Gao

et al. 2023

J. Mater. Chem. B

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“…Several different combination therapies have shown excellent anti-cervical cancer efficacy, among which gene therapy (GT)/PDT is widely used. TTC-L-M-4/DOPE was prepared by Liu and Yang et al, and used to transfer siRNA (p53) with good results, indicating that gene silencing effect was better than Lipo2000 [ 123 ]. Meanwhile, TTC-L-M-4 had the ability to effectually produce ROS under light irradiation.…”

Section: Aie-pss For Different Cancers Treatmentmentioning

confidence: 99%

Aggregation-induced emission photosensitizer-based photodynamic therapy in cancer: from chemical to clinical

et al. 2022

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Cancer remains a serious threat to human health owing to the lack of effective treatments. Photodynamic therapy (PDT) has emerged as a promising non-invasive cancer treatment that consists of three main elements: photosensitizers (PSs), light and oxygen. However, some traditional PSs are prone to aggregation-caused quenching (ACQ), leading to reduced reactive oxygen species (ROS) generation capacity. Aggregation-induced emission (AIE)-PSs, due to their distorted structure, suppress the strong molecular interactions, making them more photosensitive in the aggregated state instead. Activated by light, they can efficiently produce ROS and induce cell death. PS is one of the core factors of efficient PDT, so proceeding from the design and preparation of AIE-PSs, including how to manipulate the electron donor (D) and receptor (A) in the PSs configuration, introduce heavy atoms or metal complexes, design of Type I AIE-PSs, polymerization-enhanced photosensitization and nano-engineering approaches. Then, the preclinical experiments of AIE-PSs in treating different types of tumors, such as ovarian cancer, cervical cancer, lung cancer, breast cancer, and its great potential clinical applications are discussed. In addition, some perspectives on the further development of AIE-PSs are presented. This review hopes to stimulate the interest of researchers in different fields such as chemistry, materials science, biology, and medicine, and promote the clinical translation of AIE-PSs. Graphical Abstract

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“…Previous reports proved that the p53-mediated pathways can suppress the elimination of intracellular ROS and lipid hydroperoxides. , Meanwhile, ROS may enhance the post-translational modification of p53 and promote p53 protein stabilization and activation . Thus, the synergism between the p53 gene and PDT is a promising strategy for tumor therapy. − In particular, combination treatment of p53 and KillerRed by simultaneous codelivery of their respective reporter genes might be advantageous because such a method avoids the heterogeneity between the delivery cargos.…”

Section: Introductionmentioning

confidence: 99%

Sodium Alginate-Doping Cationic Nanoparticle As Dual Gene Delivery System for Genetically Bimodal Therapy

Zhan

Chen

et al. 2022

Biomacromolecules

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Photodynamic therapy occupies an important position in cancer therapy because of its minimal invasiveness and high spatiotemporal precision, and photodynamic/gene combined therapy is a promising strategy for additive therapeutic effects. However, the asynchronism and heterogeneity between traditional chemical photosensitizers and nucleic acid would restrict the feasibility of this strategy. KillerRed protein, as an endogenous photosensitizer, could be directly expressed and take effect in situ by transfecting KillerRed reporter genes into cells. Herein, a simple and easily prepared sodium alginate (SA)-doping cationic nanoparticle SA@GP/DNA was developed for dual gene delivery. The nanoparticles could be formed through electrostatic interaction among sodium alginate, polycation, and plasmid DNA. The title complex SA@GP/DNA showed good biocompatibility and gene transfection efficiency. Mechanism studies revealed that SA doping could facilitate the cellular uptake and DNA release. Furthermore, SA@GP/DNA was applied to the codelivery of p53 and KillerRed reporter genes for the synergistic effect combining p53-mediated apoptosis therapy and KillerRed-mediated photodynamic therapy. The ROS generation, tumor cell growth inhibition, and apoptosis assays proved that the dual-gene transfection could mediate the better effect compared with single therapy. This rationally designed dual gene codelivery nanoparticle provides an effective and promising platform for genetically bimodal therapy.

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[12]aneN₃-Conjugated AIEgens with two-photon imaging properties for synergistic gene/photodynamic therapy in vitro and in vivo

Abstract: Six amphiphiles (TTC-L-M-1/2/3/4/5/6), each consisting of hydrophilic macrocyclic polyamine triazole-[12]aneN3 (M) and hydrophobic photosensitizer tetraphenylethenethiophene modified cyanoacrylate (TTC) moiety linked with alkyl chains (L), have been designed and synthesized for...

Cited by 13 publications

References 51 publications

[12]aneN₃-modified camptothecin and PEGylated AIEgens co-assembly into core–shell nanoparticles with ROS/NTR dual-response for enhanced cancer therapy

[12]aneN₃-modified camptothecin and PEGylated AIEgens co-assembly into core–shell nanoparticles with ROS/NTR dual-response for enhanced cancer therapy

Aggregation-induced emission photosensitizer-based photodynamic therapy in cancer: from chemical to clinical

Sodium Alginate-Doping Cationic Nanoparticle As Dual Gene Delivery System for Genetically Bimodal Therapy

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[12]aneN3-Conjugated AIEgens with two-photon imaging properties for synergistic gene/photodynamic therapy in vitro and in vivo

Abstract: Six amphiphiles (TTC-L-M-1/2/3/4/5/6), each consisting of hydrophilic macrocyclic polyamine triazole-[12]aneN3 (M) and hydrophobic photosensitizer tetraphenylethenethiophene modified cyanoacrylate (TTC) moiety linked with alkyl chains (L), have been designed and synthesized for...

Cited by 13 publications

References 51 publications

[12]aneN3-modified camptothecin and PEGylated AIEgens co-assembly into core–shell nanoparticles with ROS/NTR dual-response for enhanced cancer therapy

[12]aneN3-modified camptothecin and PEGylated AIEgens co-assembly into core–shell nanoparticles with ROS/NTR dual-response for enhanced cancer therapy

Aggregation-induced emission photosensitizer-based photodynamic therapy in cancer: from chemical to clinical

Sodium Alginate-Doping Cationic Nanoparticle As Dual Gene Delivery System for Genetically Bimodal Therapy

Contact Info

Product

Resources

About

[12]aneN₃-Conjugated AIEgens with two-photon imaging properties for synergistic gene/photodynamic therapy in vitro and in vivo

[12]aneN₃-modified camptothecin and PEGylated AIEgens co-assembly into core–shell nanoparticles with ROS/NTR dual-response for enhanced cancer therapy

[12]aneN₃-modified camptothecin and PEGylated AIEgens co-assembly into core–shell nanoparticles with ROS/NTR dual-response for enhanced cancer therapy