2006
DOI: 10.1002/lt.20802
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12-month follow-up analysis of a multicenter, randomized, prospective trial in de novo liver transplant recipients (LIS2T) comparing cyclosporine microemulsion (C2 monitoring) and tacrolimus

Abstract: The LIS2T study was an open-label, multicenter study in which recipients of a primary liver transplant were randomized to cyclosporine microemulsion (CsA-ME) (Neoral) (n ϭ 250) (monitoring of blood concentration at 2 hours postdose) C 2 or tacrolimus (n ϭ 245) (monitoring of trough drug blood level [predose]) C 0 to compare efficacy and safety at 3 and 6 months and to evaluate patient status at 12 months. All patients received steroids with or without azathioprine. At 12 months, 85% of CsA-ME patients and 86% … Show more

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Cited by 90 publications
(59 citation statements)
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“…69 In the multicenter LIS2T study, Levy et al found no difference between Cyclosporine (250 patients) or Tacrolimus (245 patients) regarding HCV recurrence, although mean time for histological diagnosis of HCV recurrence was significantly longer in the Cyclosporine group. 70 Steroid free regimens are not associated with less hepatitis C recurrence as compared to steroids based regimens. However, use of steroid boluses is clearly associated with more severe recurrence and should be avoided.…”
Section: Hepatitis C Virus (Hcv) Recurrencementioning
confidence: 99%
“…69 In the multicenter LIS2T study, Levy et al found no difference between Cyclosporine (250 patients) or Tacrolimus (245 patients) regarding HCV recurrence, although mean time for histological diagnosis of HCV recurrence was significantly longer in the Cyclosporine group. 70 Steroid free regimens are not associated with less hepatitis C recurrence as compared to steroids based regimens. However, use of steroid boluses is clearly associated with more severe recurrence and should be avoided.…”
Section: Hepatitis C Virus (Hcv) Recurrencementioning
confidence: 99%
“…61 In a prospective randomized controlled study of 495 recipients with HCV infection, no difference was seen in the histologic recurrence rate of hepatitis C at 12 months after transplant between patients receiving cyclosporine versus tacrolimus. 62 A meta-analysis of studies comparing the 2 calcineurin inhibitors found a patient and graft survival benefit associated with tacrolimus as maintenance immunosuppression. 63 Conversely, some reports have shown that cyclosporine may have an inhibitory effect on HCV replication that requires concomitant administration of interferon 64 ; however, a prospective, randomized, pilot study revealed no significant difference in sustained viral response compared with those who received tacrolimus.…”
Section: Lines Of Managementmentioning
confidence: 99%
“…Rá-adásul a tacrolimus a STAT-1 foszforilációján és nukleáris transzlokációján keresztül gátolja az interferon jelátviteli utat, ezáltal növelve a vírusreplikációt [31]. Összességében nagy, randomizált vizsgálatok nem találtak érdemi különbséget HCV-pozitív májátültetett betegek körében a kumulatív beteg-és grafttúlélésben Tac vagy CyA alkalmazása esetén [32]. Jelen vizsgála-tunkban a HCV-pozitív betegek közül többen részesül-tek CyA-alapú immunszuppressziós kezelésben, mint a nem HCV-negatív betegek (20% vs. 6%), összességében és döntően azonban a bázis-immunszuppressziós kezelés ebben az időszakban mindkét csoportban tacrolimusalapú volt.…”
Section: Megbeszélésunclassified