12(S)-HETE in Cancer Metastasis

Tang, K.; Honn, Kenneth V.

doi:10.1007/978-1-4615-4861-4_17

Cited by 45 publications

(18 citation statements)

References 67 publications

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“…21 More recently, multiple reports have described the presence of lipoxygenase enzymes in prostate cancer and prostatic carcinoma cell lines. Gao et al 10 10 Biological effects of 12-HETE include promotion of tumor cell adhesion and endothelial cell contraction, indicating a potential contribution to tumor cell metastasis 2,22,23 and possible modulation of tumor growth by induction of angiogenesis. 24 12-LOX enzyme activity has not been reported in actual prostate tissues or prostate cancers, however.…”

Section: Discussionmentioning

confidence: 99%

15-Lipoxygenase-2 (15-LOX-2) Is Expressed in Benign Prostatic Epithelium and Reduced in Prostate Adenocarcinoma

Shappell

Boeglin

Olson

et al. 1999

The American Journal of Pathology

141

120

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Human 15S-lipoxygenase-2 (15-LOX-2) is a recently identified lipoxygenase that has approximately 40% sequence identity to the known human 5S-, 12S-, and 15S-lipoxygenases. 15-LOX-2 has a limited tissue dis-Arachidonic acid (AA) metabolites are important mediators of a variety of physiological processes and inflammatory reactions. In addition, alterations in AA metabolism may potentially mediate key steps in certain neoplastic processes. 1-3 AA is metabolized via cyclooxygenase to prostaglandins, prostacyclin, and thromboxane, 4 and via lipoxygenases (LOX) to hydroxyeicosatetraenoic acids (HETEs) or leukotrienes (5-LOX pathway). 5,6 Until recently, three lipoxygenases were recognized in humans: a 5S-LOX found in leukocytes, a 12S-LOX found in platelets and certain epithelia, and a 15S-LOX in reticulocytes, eosinophils, macrophages, and skin. 7 Recently, in studying lipoxygenase expression in human skin, Brash et al 8 discovered a second 15S-lipoxygenase (herein referred to as 15-LOX-2). The cDNA-derived amino acid sequence of 15-LOX-2 showed only 44% identity to 5-LOX and 38% to 39% identity to 12-LOX and the reticulocyte type of 15-LOX

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Section: Discussionmentioning

confidence: 99%

15-Lipoxygenase-2 (15-LOX-2) Is Expressed in Benign Prostatic Epithelium and Reduced in Prostate Adenocarcinoma

Shappell

Boeglin

Olson

et al. 1999

The American Journal of Pathology

141

120

View full text Add to dashboard Cite

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“…It is possible that initial interactions via cell adhesion molecules may trigger the dissolution of the endothelial junctional complexes. On the other hand, several recent reports have suggested a role for gap junctions that are formed at contact sites between tumor cells and endothelial cells Pauli, 1991, 1994;Honn et al, 1994;Tang and Honn, 1994a). These gap junctions are thought to permit the transfer of 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE), a lipoxygenase metabolite of arachidonic acid, from tumor cells to endothelial cells, eventually leading to the retraction of endothelial cells.…”

Section: Involvement Of Other Cell Adhesion Molecules In Transendothementioning

confidence: 96%

Cell-cell interactions during transendothelial migration of tumor cells

Voura

Sandig

Siu

1998

Microsc. Res. Tech.

107

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“…Extensive research has been focused on PGs and other COX-derived metabolites. However, a number of studies suggested that LOX-derived products also affect the development and progression of several malignancies (21)(22)(23)(24)(25).…”

Section: Nsaidsmentioning

confidence: 99%