12(S)-HPETE induces itch-associated scratchings in mice

Dae-Kwon, Kim; Kim, Hyung-June; Sung, Ki-Sa; Kim, Hyuk; Cho, Sun-A; Kim, Kwang-Mi; Lee, Chang‐Hoon; Kim, Jung‐Ju

doi:10.1016/j.ejphar.2006.09.057

Cited by 18 publications

(16 citation statements)

References 17 publications

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“…The role of LTB 4 in neutrophil recruitment to the skin is supported by the observation that epicutaneous application of LTB 4 in normal healthy volunteers results in local neutrophil infiltration (de Jong et al, 1992). LTB 4 induces itch-associated scratching response in mice (Kim et al, 2007). Tape stripping induced significantly more scratching in WT mice than in Ltb4r1 −/− and Lta4h −/− mice, suggesting that LTB 4 is important in the scratching response to mechanical injury.…”

Section: Discussionmentioning

confidence: 62%

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Leukotriene B4 Driven Neutrophil Recruitment to the Skin Is Essential for Allergic Skin Inflammation

Oyoshi

et al. 2013

Journal of Allergy and Clinical Immunology

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SummaryScratching triggers skin flares in atopic dermatitis (AD). We demonstrate that scratching of human skin, and tape stripping of mouse skin, causes neutrophil influx. This influx in mice was largely dependent on the generation of leukotriene B 4 (LTB 4 ) by neutrophils and their expression of the LTB 4 receptor BLT1. Allergic skin inflammation in response to epicutaneous (EC) application of ovalbumin to tape-stripped skin was severely impaired in Ltb4r1 −/− mice, and required expression of BLT1 on both T cells and non-T cells. Co-transfer of WT neutrophils, but not neutrophils deficient in BLT1 or the LTB 4 synthesizing enzyme LTA 4 H, restored the ability of WT CD4 + effector T cells to transfer allergic skin inflammation to Ltb4r1 −/− recipients. Pharmacologic Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access

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Section: Discussionmentioning

confidence: 62%

“…6E,F). LTB 4 induces itch-associated scratching response in mice (Kim et al, 2007). Tape stripping induced significantly more scratching in WT mice than in Ltb4r1 −/− and Lta4h −/− mice, suggesting that LTB 4 is important in the scratching response to mechanical injury (Fig.…”

Section: Neutrophil-derived Ltb 4 Is Important For the Development Ofmentioning

confidence: 99%

Leukotriene B4 Driven Neutrophil Recruitment to the Skin Is Essential for Allergic Skin Inflammation

Oyoshi

et al. 2013

Journal of Allergy and Clinical Immunology

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“…LTB 4 induces itch-associated scratching response in mice (Kim et al, 2007). Tape stripping induced significantly more scratching in WT mice than in Ltb4r1 −/− and Lta4h −/− mice, suggesting that LTB 4 is important in the scratching response to mechanical injury (Fig.…”

Section: Resultsmentioning

confidence: 99%

Leukotriene B4-Driven Neutrophil Recruitment to the Skin Is Essential for Allergic Skin Inflammation

et al. 2012

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Summary Scratching triggers skin flares in atopic dermatitis (AD). We demonstrate that scratching of human skin, and tape stripping of mouse skin, causes neutrophil influx. This influx in mice was largely dependent on the generation of leukotriene B4 (LTB4) by neutrophils and their expression of the LTB4 receptor BLT1. Allergic skin inflammation in response to epicutaneous (EC) application of ovalbumin to tape-stripped skin was severely impaired in Ltb4r1−/− mice, and required expression of BLT1 on both T cells and non-T cells. Co-transfer of WT neutrophils, but not neutrophils deficient in BLT1 or the LTB4 synthesizing enzyme LTA4H, restored the ability of WT CD4+ effector T cells to transfer allergic skin inflammation to Ltb4r1−/− recipients. Pharmacologic blockade of LTB4 synthesis inhibited allergic skin inflammation elicited by cutaneous antigen challenge in previously EC-sensitized mice. Our results demonstrate that a neutrophil-T cell axis reliant on LTB4-BLT1 interaction is required for allergic skin inflammation.

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“…Intradermal injection of LTB4 elicits scratching in mice through the LTB4 receptor-1 (BLT1) receptor (Andoh and Kuraishi, 1998b, Andoh and Kuraishi, 2005), while 12-lipoxigenase metabolites elicit scratching via the LTB4 receptor-2 (BLT2) receptor (Dae-Kwon et al, 2007, Kim et al, 2008a). LTB4 is a downstream mediator of scratching evoked by SP as well as sphingosylphosphorylcholine (SPC) (Andoh et al, 2009).…”

Section: Pruritogensmentioning

confidence: 99%

Neural processing of itch

2013

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While considerable effort has been made to investigate the neural mechanisms of pain, much less effort has been devoted to itch, at least until recently. However, itch is now gaining increasing recognition as a widespread and costly medical and socioeconomic issue. This is accompanied by increasing interest in the underlying neural mechanisms of itch, which has become a vibrant and rapidly-advancing field of research. The goal of the present forefront review is to describe the recent progress that has been made in our understanding of itch mechanisms.

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12(S)-HPETE induces itch-associated scratchings in mice

Cited by 18 publications

References 17 publications

Leukotriene B4 Driven Neutrophil Recruitment to the Skin Is Essential for Allergic Skin Inflammation

Leukotriene B4 Driven Neutrophil Recruitment to the Skin Is Essential for Allergic Skin Inflammation

Leukotriene B4-Driven Neutrophil Recruitment to the Skin Is Essential for Allergic Skin Inflammation

Neural processing of itch

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