2023
DOI: 10.1093/annweh/wxac087.163
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123 Finding Optimal Methods for SbD Hazard Testing of Nanomaterials: The Effect of Cell Model and Exposure Method on Cytokine Response

Abstract: The concept of safe-by-design (SbD) can help toxicologists and risk assessors to keep pace with the rapidly expanding field of nanotechnology. As part of SbD, the hazard potential of a new nanomaterial (NM) is identified at the first stages of product development. For this, simple yet predictive toxicity assays are crucial. We investigated the suitability of several in vitro models and exposure methods to predict the human (pulmonary) inflammation potential of NMs. Four silica NMs were selected of which in viv… Show more

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