123I-2-iodo-tyrosine, a new tumour imaging agent: human biodistribution, dosimetry and initial clinical evaluation in glioma patients

Keyaerts, Marleen; Lahoutte, Tony; Neyns, Bart; Caveliers, Vicky; Vanhove, Christian; Everaert, Hendrik; Kersemans, Ken; Franken, Philippe; Mertens, John; Bossuyt, Axel

doi:10.1007/s00259-006-0303-3

Cited by 8 publications

(2 citation statements)

References 17 publications

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“…Radiolabeled methionine (L- (190). In addition, the alicyclic amino acid derivatives 1-aminocyclobutane-11 C-carboxylic acid ( 11 C-ACBC) (191) and anti-1-amino-3-18 F-fluorocyclobutyl-1-carboxylic acid ( 18 F-FACBC) (192) have been shown to accumulate in several human tumors (193).…”

Section: Imaging Of Amino Acid Transportmentioning

confidence: 99%

Tumor Cell Metabolism Imaging

Plathow¹,

Weber²

2008

J Nucl Med

278

222

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Molecular imaging of tumor metabolism has gained considerable interest, since preclinical studies have indicated a close relationship between the activation of various oncogenes and alterations of cellular metabolism. Furthermore, several clinical trials have shown that metabolic imaging can significantly impact patient management by improving tumor staging, restaging, radiation treatment planning, and monitoring of tumor response to therapy. In this review, we summarize recent data on the molecular mechanisms underlying the increased metabolic activity of cancer cells and discuss imaging techniques for studies of tumor glucose, lipid, and amino acid metabolism.

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Section: Imaging Of Amino Acid Transportmentioning

confidence: 99%

Tumor Cell Metabolism Imaging

Plathow¹,

Weber²

2008

J Nucl Med

278

222

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“…2). A number of other radiolabeled aromatic amino acids have been reported including 3-[ 18 F]fluoroalpha-methyl-L-tyrosine, 2-[ 18 F]fluoro-L-tyrosine, 2-[ 18 F] fluoromethyl-L-phenylalanine, O-[ 18 F]fluoromethyl tyrosine, O-[ 18 F]fluoropropyl tyrosine and 2-[ 123 I]iodo-tyrosine[72,73,78,[90][91][92][93]. The development and evaluation of this class of radiolabeled amino acids remains an active area of investigation.…”

mentioning

confidence: 98%

Non-natural amino acids for tumor imaging using positron emission tomography and single photon emission computed tomography

McConathy

Goodman

2008

Cancer Metastasis Rev

109

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Amino acids are required nutrients for proliferating tumor cells, and amino acid transport is upregulated in many tumor types. Studies of radiolabeled amino acids in animals and humans demonstrate that amino acid based tracers have advantageous characteristics relative to 2-[(18)F]fluoro-2-deoxyglucose in certain tumors, particularly brain gliomas. Non-natural amino acids for tumor imaging generally have greater metabolic stability and can be labeled with longer-lived radionuclides for positron emission tomography and single photon emission computed tomography such as fluorine-18 and iodine-123. Amino acids enter cells via amino acid transport with varying selectivity based on their chemical structure. This review focuses on the rationale, biological basis, current status and future prospects of radiolabeled non-natural amino acids for tumor imaging and discusses various classes of these compounds including aromatic, alicyclic and alpha,alpha-dialkyl amino acids.

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Advances in Radiotracer Development for Molecular Imaging

Liu

2014

Molecular Imaging of Small Animals

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123I-2-iodo-tyrosine, a new tumour imaging agent: human biodistribution, dosimetry and initial clinical evaluation in glioma patients

Abstract: 123I-2IT has a favourable biodistribution for a tumour imaging agent. It shows increased uptake in central nervous system glioma and is potentially useful in the follow-up of glioma patients.

Cited by 8 publications

References 17 publications

Tumor Cell Metabolism Imaging

Tumor Cell Metabolism Imaging

Non-natural amino acids for tumor imaging using positron emission tomography and single photon emission computed tomography

Advances in Radiotracer Development for Molecular Imaging

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