125 - Effects of Fecal Microbiota Transplantation on DSS-Induced Colitis Mice May Partly Owing to Enhanced Polarization of Macrophage M2

Intestinal anti-inflammatory effects of artichoke pectin and modified pectin fractions in the dextran sulfate sodium model of mice colitis. Artificial neural network modelling of inflammatory markers

“…Faecal microbiota transplantation combined with pectin in DSS-induced colitis mice enhanced its positive effects on the colonic ratio and DAI and reduced the expression of TNF-α, IL-1β and IL-6. 31 A reduction in IL-1β, IL-6, and TNF-α in the murine model of endotoxin shock has also been reported for CP treatment, as well as a decrease in IL-6 secretion from Toll-like receptor-activated RAW264.7 pretreated with CP. However, when this study was performed using polygalacturonic acid, treatment was not effective, highlighting the importance of neutral sugars present in side chains of pectin.…”