125I-serum albumin assay of edema in rat skin with and without vasoconstriction after cryosurgery type freezing

Vascular responses in the oral mucosa following cryosurgery

“…to 1 hr. after cryosorgery as meastired by carbon particle retention, is in agreement with the serum dye experiments reported previously in which maximum permeability was seen at a comparable time interval and supports the work of Rothenborg (1972) using radioactive labelled albumin.…”

“…The increasing permeability of vessels following cryosurgery has been qpantitated by Rothenborg (1972) but not related to vessel type. A recent study at the electron microscopic level (Whittaker 1975) has implicated both capillaries and venules in the response but the technique does not lend itself to quantitative assesstnent.…”

An ultrastructural study of initial changes in epithelium damaged by surface freezing

“…It has been shown by previous workers that ischaemia does not normally develop for some time after surface freezing (Rothenborg, 1972) and the present investigation is of early epithelial changes following freezing and thawing in the interval before ischaemic changes would be expected to be of importance (Willms-Kretschmer and Majno, 1969).…”

“Third Generation” Cryotherapy

“…The object of the present article is to outline some of the steps which we think are necessary to obtain full control of different factors that influence the result of cryosurgical operations. A good deal of the experience upon which suggestions are offered below has been gained from experimental work,,, in which it was of prime importance that the cryosurgical procedure be fully under control and reproducible. The technological problems of that experimental work were identical to those encountered in cryosurgical operation on patients, and it was thus found permissible to draw conclusions from the experimental to the clinical situation.…”