128 Cumulative oral corticosteroid use increases risk of glucocorticoid-related adverse events in patients with pemphigus

Abstract

Previous studies have suggested that psoriasis is associated with liver disease, possibly related to metabolic co-morbidities, alcohol consumption, treatment toxicity, and chronic inflammation. The objective of this study was to determine if psoriasis increases risk for incident liver disease after controlling for traditional risk factors for liver disease. We conducted a population-based cohort study in the United Kingdom using The Health Improvement Network (THIN) data from 1994-2014 to investigate the risk of liver disease in psoriasis patients. Patients with a history of liver disease were excluded from the analyses. Diagnostic codes were used to identify psoriasis patients. Patients who received systemic or phototherapy were classified as having moderate to severe psoriasis. Each exposed patient had up to 5 matched controls. Cox proportional hazards models were used to estimate hazard ratios with 95% confidence intervals. Psoriasis patients were at a significantly higher risk for developing liver disease (mild PsO: