13 CO 2 breath tests in non-invasive hepatological diagnosis

Musialik, Joanna; Jonderko, Krzysztof; Kasicka-Jonderko, Anna; Buschhaus, Magdalena

doi:10.5114/pg.2014.47501

Cited by 4 publications

(4 citation statements)

References 32 publications

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“…In addition, tumor stage may also affect the body's amino acid levels. It was reported that the concentration of tyrosine, methionine and phenylalanine in patients with hepatocellular carcinoma increased with tumor stage [25]. However, due to the small sample size of this study, we did not carry out the study of staging and amino acid metabolism.…”

Section: Discussionmentioning

confidence: 99%

Metabonomics studies on serum and urine of patients with breast cancer using 1H-NMR spectroscopy

Zhou¹,

Wang²,

Zhang³

2017

Oncotarget

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The aim of this study was to describe a metabolomic study of breast cancer using 1 H-NMR combined with bioinformatics analysis. 1 H-NMR spectroscopy combined with multi-variate pattern recognition analysis was used to cluster the groups (serum and urine samples from breast cancer patients and healthy controls) and establish a breast-cancer-specific metabolites phenotype. Orthogonalpartial least-squares discriminant analysis (OPLS-DA) was capable of distinguishing serum and urine samples from breast cancer patients and healthy controls and establishing a breastcancer-specific metabolite profile. A total of 9 metabolites in serum concentration and 3 metabolites in urine concentration differed significantly between breast cancer patients and healthy controls. Serum samples from breast cancer patients were characterized by decreased concentrations of choline, glucose, histidine, valine, lysine, acetate, tyrosine and glutamic, accompanied by increased concentrations of lipid relative to healthy controls. In urine samples, the level of phenylacetylglycine and guanidoacetate was significantly lower, while the level of citrate was significantly higher in breast cancer patients relative to healthy controls. In conclusion, this study reveals the metabolic profile of serum and urine from breast cancer patients. NMRbased metabolomics has the potential to be developed into a novel clinical tool for diagnosis or therapeutic monitoring for breast cancer. However, because of limitations of methods and technique, further research and verification is needed.

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Section: Discussionmentioning

confidence: 99%

Metabonomics studies on serum and urine of patients with breast cancer using 1H-NMR spectroscopy

Zhou¹,

Wang²,

Zhang³

2017

Oncotarget

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“…Thus, in the presence of steatosis, it is observed the shift of the peak metabolism rate from 10 minutes to 20-30-40-50 minutes of the test [3,6]. The progression of the pathological process leads to a decrease in the rate of metabolism and in the cumulative dose that characterizes the "capacity" of the liver [9]. However, for early diagnosis of NAFLD, it is important to evaluate the cumulative dose accumulation during the examination [3,9].…”

Section: Discussionmentioning

confidence: 99%

“…The progression of the pathological process leads to a decrease in the rate of metabolism and in the cumulative dose that characterizes the "capacity" of the liver [9]. However, for early diagnosis of NAFLD, it is important to evaluate the cumulative dose accumulation during the examination [3,9]. Thus, the points for difference between normal condition and pathology are metabolism levels of 1.05 at 10 minutes, 4.15 at 20 minutes, 7.15 at 30 minutes, 9.00 at 40 minutes, and 20.00 at 120 minutes [6].…”

Section: Discussionmentioning

confidence: 99%

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13c-Methacetin Breathe Test in Early Diagnostics of Non-Alcoholic Fatty Liver Disease

Sklyarova

2021

Wiad Lek

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The aim: Of the study was to evaluate the early utility changes of the 13C methacetin breath test parameters in patients with NAFLD. Materials and methods: There were included 50 subjects in the study, among them 35 patients had steatosis and 15 patients had steatohepatitis, including 35 (70.0%) male subjects and 15 (30.0%) female subjects. The control group included 17 apparently healthy volunteers, among them 10 (58.8%) subjects were male and 7 (41.2%) subjects were female. Results: It was determined that metabolism kinetics in case of liver steatosis was significant decreased more than 30% compared to the control group (p = 0.0001) and in case of steatohepatitis that decrease was more than 65% (p = 0.00001) compared with normal values. It resulted in less cumulative dose accumulation in steatosis (p = 0.00001) and steatohepatitis (p = 0.00001). Among the reasons for the decrease in the kinetics of metabolism in steatosis, there were insufficient response of hepatocytes on 10 minutes (<10 dose/h,%) in 40% of cases and reduction of metabolism rate amplitude at 20-40 minutes following methacetin administration. Conclusions: The results of 13C-methacetin breath test demonstrate that in patients with NAFLD there is a gradual slowing of metabolism rate in hepatocytes, which leads to a decrease in cumulative dose.

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Toxicity of 13C-labeled linoleic and linolenic acids for diagnostic breath tests

Tynio

Морозова

Бирюкова

et al. 2019

BRSMU

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Noninvasive stable isotope breath tests allow highly accurate and safe estimation of liver and biliary tract function. The aim of this study was to test 13С-labeled linoleic and linolenic acids intended for diagnostic use for acute and subchronic toxicity. The acids were synthesized using the patented method. A single intragastric administration of the tested compounds to experimental BALB/c mice and Wistar rats in the amounts exceeding clinical doses 500 to 2500-fold did not cause animal death. In the subchronic toxicity test, the rats received 5 to 25 times higher doses than recommended for clinical use in humans. In a 14-day follow-up period, no significant differences were observed between the main and the control groups in terms of weight, blood count (red blood cells, white blood cells, platelets), and blood biochemistry (hemoglobin, total protein, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, bilirubin). The studied compounds are safe at doses intended for oral administration and are recommended for further preclinical and clinical trials.

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13 CO 2 breath tests in non-invasive hepatological diagnosis

Cited by 4 publications

References 32 publications

Metabonomics studies on serum and urine of patients with breast cancer using 1H-NMR spectroscopy

Metabonomics studies on serum and urine of patients with breast cancer using 1H-NMR spectroscopy

13c-Methacetin Breathe Test in Early Diagnostics of Non-Alcoholic Fatty Liver Disease

Toxicity of 13C-labeled linoleic and linolenic acids for diagnostic breath tests

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