13-Hydroxyoctadecadienoic acid attenuates oedema formation induced by leukotriene B4 in vivo in rabbit skin

Buckley, Theresa L.; Velde, Marco J. van de; Henricks, Paul A.J.; Engels, Ferdi; Nijkamp, Frans P.

doi:10.1016/0014-2999(92)90195-a

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…Thus, regarding potential functions of basally expressed sPLA 2 , it is tempting to speculate that they might be involved in keratinocyte hyperproliferation during in£ammatory processes. On the other hand, because of their broad substrate speci¢city, sPLA 2 s may also produce fatty acids, such as linoleic acid and some of its metabolites, which in turn promote anti-in£ammatory functions and oppose their e¡ects to those of cPLA 2 s and its lipid mediator products (Buckley et al, 1992;Fischer et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Differentiation-Dependent Regulation of Secreted Phospholipases A2 in Murine Epidermis

Gurrieri

Fürstenberger

Schadow

et al. 2003

Journal of Investigative Dermatology

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The action of secreted phospholipases A2 in skin is thought to be essential for epidermal barrier homeostasis. The incomplete knowledge of presence and functions of the novel secreted phospholipase A2 subtypes in skin prompted us to explore their expression in epidermis and primary keratinocytes from murine neonatal skin. We detected secreted phospholipases A2-IB, -IIA, -IIC, -IID, -IIE, -IIF, -V, -X, and -XII. To study secreted phospholipase A2 expression during epidermal differentiation, primary keratinocytes from the basal, suprabasal, and upper differentiated layers of neonatal mouse epidermis were obtained by density gradient centrifugation. mRNA for secreted phospholipases A2-IB, -IIE, -IIF, -V, and -XII-1 are mainly expressed in the upper differentiated layers, whereas the most prominent enzymes in the basal and suprabasal layers are secreted phospholipases A2-IIA, -IID, and -X. The mRNA for secreted phospholipase A2-IIC was found in all fractions. Immunohistochemical analysis in mouse skin sections reflected the mRNA distribution patterns in the different epidermal cell fractions. After in vitro induction of keratinocyte differentiation by increasing the calcium concentration of the medium, secreted phospholipases A2-IB, -IIE, -IIF, -V, and -XII-1 were upregulated, whereas secreted phospholipases A2-IIA, -IIC, -IID, and -X were mainly expressed in proliferating keratinocytes. The specific secreted phospholipase A2 expression profile in the skin suggests a distinct function for each enzyme in the epidermis.

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Section: Discussionmentioning

confidence: 99%

Differentiation-Dependent Regulation of Secreted Phospholipases A2 in Murine Epidermis

Gurrieri

Fürstenberger

Schadow

et al. 2003

Journal of Investigative Dermatology

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“…induced bronchial hyperreactivity to histamine in vivo (Henricks et al, 1991a) and was found to inhibit oedema formation induced by leukotriene B4 in the presence of calcitonin gene-' Author for correspondence. related peptide (CGRP) in rabbit skin (Buckley et al, 1992). In this study we investigated the effect of 13-HODE on blood pressure in the rat.…”

Section: Introductionmentioning

confidence: 99%

Hypotensive effect of 13‐hydroxylinoleic acid in the rat: mediation via the release of a CGRP‐like mediator from capsaicin‐sensitive nerves

Heuven-Nolsen

Muis

Engels

et al. 1995

British J Pharmacology

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1. The effect of 13-hydroxylinoleic acid (13-HODE) on changes in blood pressure in the rat was measured. 2. 13-HODE (0.1 - 100 micrograms kg-1) had no direct effect on blood pressure in the rat and had no effect on histamine (0.1 - 1000 micrograms kg-1)-induced changes in blood pressure. In contrast, it was found that 13-HODE itself induced a decrease in diastolic arterial blood pressure when it was injected intravenously after either a single dose of histamine (10, 100 or 1000 micrograms kg-1) or after a dose-response curve of histamine (0.1 - 1000 micrograms kg-1). 3. This hypotensive effect of 13-HODE was not observed after administration of the endothelium-dependent vasodilator, acetylcholine (0.1 - 10 micrograms kg-1), the endothelium-independent vasodilator, sodium nitroprusside (0.1 - 100 micrograms kg-1) or the inflammatory mediator, leukotriene B4 (0.1 - 300 micrograms kg-1). However, prior injection of bradykinin (0.1 - 100 micrograms kg-1) allowed a dose-dependent hypotensive effect of 13-HODE to be revealed. 4. The hypotensive effect of 13-HODE after histamine and bradykinin could be inhibited by neonatal capsaicin treatment of the rats (50 mg kg-1, s.c. on day 1 and 2 after birth). 5. Ruthenium red (120 micrograms kg-1 min-1), an inhibitor of excitatory effects on sensory nerves, and the CGRP antagonist, CGRP8-37 (1-3 micrograms kg-1 min-1) also inhibited the hypotensive effect of 13-HODE. 6. It is concluded that the hypotensive effect of 13-HODE in the rat after histamine and bradykinin is due to the release of a CGRP-like substance from sensory nerves. These results highlight the possibility that endogenous 13-HODE could be involved in the neurogenic regulation of blood pressure.

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Eicosanoids, fatty acids and neutrophils: Their relevance to the pathophysiology of disease

Bates

1995

Prostaglandins, Leukotrienes and Essential Fatty Acids

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13-Hydroxyoctadecadienoic acid attenuates oedema formation induced by leukotriene B4 in vivo in rabbit skin

Cited by 6 publications

References 11 publications

Differentiation-Dependent Regulation of Secreted Phospholipases A2 in Murine Epidermis

Differentiation-Dependent Regulation of Secreted Phospholipases A2 in Murine Epidermis

Hypotensive effect of 13‐hydroxylinoleic acid in the rat: mediation via the release of a CGRP‐like mediator from capsaicin‐sensitive nerves

Eicosanoids, fatty acids and neutrophils: Their relevance to the pathophysiology of disease

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