2023
DOI: 10.1155/2023/7855924
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13-cis-Retinoic Acid Affects Brain Perfusion and Function: In Vivo Study

Abstract: Purpose. Study the effects of 13-cis-retinoic acid (13-RA), a synthetic analogue of a vitamin A used for the treatment of severe acne, on the blood flow in the rat brain using technetium-99m hexamethyl propylene amine oxime (99mTc-HMPAO) imaging. Methods. A total of 30 adult male Wistar rats were divided into the control (C), low-dose (L), and high-dose (H) groups. The L and H rats were exposed subcutaneously to 0.3 and 0.5 mg, respectively, of 13-RA per kg of body weight for seven days. Brain blood flow imagi… Show more

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“…To study the brain blood flow, animals were anesthetized, injected intravenously with 111 MBq of 99m Tc-HMPAO, then imaged with a single-head gamma (γ) camera (Philips camera; Odyssey LX) equipped with a high-resolution parallel hole collimator connected to a Dell computer [44]. The matrix was 64 × 64 pixels, and the photo peak was focused at 140 keV with a AGING symmetric 10% window.…”
Section: M Tc-hmpao Brain Flow Gamma Camera Imaging and Processingmentioning
confidence: 99%
“…To study the brain blood flow, animals were anesthetized, injected intravenously with 111 MBq of 99m Tc-HMPAO, then imaged with a single-head gamma (γ) camera (Philips camera; Odyssey LX) equipped with a high-resolution parallel hole collimator connected to a Dell computer [44]. The matrix was 64 × 64 pixels, and the photo peak was focused at 140 keV with a AGING symmetric 10% window.…”
Section: M Tc-hmpao Brain Flow Gamma Camera Imaging and Processingmentioning
confidence: 99%