13-Oxyingenol-dodecanoate inhibits the growth of non-small cell lung cancer cells by targeting ULK1

Wang, Xin-Ye; Wang, Yu-Jue; Guo, Bo-Wen; Hou, Zi-Lin; Zhang, Gu-Xue; Han, Zheng; Liu, Qingbo; Yao, Guo-Dong; Song, Shao-Jiang

doi:10.1016/j.bioorg.2024.107367

Bioorganic Chemistry

2024

DOI: 10.1016/j.bioorg.2024.107367

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13-Oxyingenol-dodecanoate inhibits the growth of non-small cell lung cancer cells by targeting ULK1

Xin-Ye Wang,

Yu-Jue Wang,

Bo-Wen Guo

et al.

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The Interplay between Autophagy and Mitochondria in Cancer

Zdanowicz,

Grosicka-Maciąg

2024

IJMS

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Besides producing cellular energy, mitochondria are crucial in controlling oxidative stress and modulating cellular metabolism, particularly under stressful conditions. A key aspect of this regulatory role involves the recycling process of autophagy, which helps to sustain energy homeostasis. Autophagy, a lysosome-dependent degradation pathway, plays a fundamental role in maintaining cellular homeostasis by degrading damaged organelles and misfolded proteins. In the context of tumor formation, autophagy significantly influences cancer metabolism and chemotherapy resistance, contributing to both tumor suppression and surveillance. This review focuses on the relationship between mitochondria and autophagy, specifically in the context of cancer progression. Investigating the interaction between autophagy and mitochondria reveals new possibilities for cancer treatments and may result in the development of more effective therapies targeting mitochondria, which could have significant implications for cancer treatment. Additionally, this review highlights the increasing understanding of autophagy’s role in tumor development, with a focus on modulating mitochondrial function and autophagy in both pre-clinical and clinical cancer research. It also explores the potential for developing more-targeted and personalized therapies by investigating autophagy-related biomarkers.

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The Interplay between Autophagy and Mitochondria in Cancer

Zdanowicz,

Grosicka-Maciąg

2024

IJMS

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scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

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13-Oxyingenol-dodecanoate inhibits the growth of non-small cell lung cancer cells by targeting ULK1

Cited by 1 publication

References 45 publications

The Interplay between Autophagy and Mitochondria in Cancer

The Interplay between Autophagy and Mitochondria in Cancer

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