13 STR loci frequencies in the population from Paraíba, Northeast Brazil

Gomes, Ana Cláudia Amorim; Maurício-da-Silva, Luiz; Raposo, Glória; Vieira, Jeymesson Raphael Cardoso; Silva, Rosilda dos Santos

doi:10.1016/j.forsciint.2006.10.026

Cited by 11 publications

(10 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The values for PIC obtained in this study were higher than 0.6 for every locus analyzed, ranging from 0.6905 (TPOX) to 0.93 (SE33), which means that each of the 25 loci analyzed were highly polymorphic, and would contribute to the genetic variation of the analyzed population. Previous studies in other populations realized with PIC have shown similar results within some of the analyzed loci: TPOX, CSF1PO, PENTA E, FGA, and TH01 [ 11 , 12 , 13 ]. Due to the number of loci analyzed in the present study, further comparisons were not possible with the published studies.…”

Section: Discussionsupporting

confidence: 71%

“…TH01, DS2441, TPOX, and CSF1PO presented the highest PI values in our analysis, ranging from 0.1046 (CSF1PO) to 0.113 (TH01). Previously available studies on TH01, TPOX, and CSF1PO in northeastern Brazil have shown similarities in values for PI in these same loci [ 10 , 11 , 12 ]. The PI range must fall between 0 and 1 [ 9 ], and thus, given the values obtained, every locus analyzed in this study presented a considerable difference when comparing genotypes in the studied population, confirming the high genetic variability of Bahia’s population.…”

Section: Discussionmentioning

confidence: 91%

“…Among observed studies, the most polymorphic loci were D2S1338, D18S51, D21S11, PENTA E, FGA, and SE33. In all studies, the least polymorphic locus was TPOX [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. This study of Bahia’s population identified the SE33, D21S11, and FGA loci as having the highest polymorphism, with SE33 being found only in the Portuguese, Brazilian, and Northeastern Brazil studies [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition to allelic analysis, the present study provides statistical and forensic data for the 25 analyzed STR loci in Bahia’s population. Other Brazilian studies realized in this category present an average of 8 to 13 analyzed loci [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. The present study thus promotes greater quantitative certainty for the genetic data of the Brazilian population.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Allele Frequencies and Forensic Data of 25 STR Markers for Individuals in Northeast Brazil

Santos

Filho

Silva

et al. 2023

Genes

View full text Add to dashboard Cite

Identifying DNA markers such as Short Tandem Repeats (STR) can be used to investigate genetic diversity based on levels of heterozygosity within and between populations. Allele frequencies and forensic data for STRs were obtained from a sample of 384 unrelated individuals living in Bahia, Northeastern Brazil. Thus, the present study aimed to identify the allele frequency distribution, in addition to the forensic and genetic data, of 25 STR loci in the population of Bahia. Buccal swabs or fingertip punctures were utilized to amplify and detect 25 DNA markers. The most polymorphic loci were SE33 (43), D21S11, and FGA (21). The least polymorphic were TH01 (6), TPOX, and D3S1358 (7). Forensic and statistical data were obtained through data analysis, which revealed a large genetic diversity, with an average value of 0.813 for the analyzed population. The present study was more robust than previous STR marker studies and will contribute to future research on population genetics in Brazil and worldwide. The results of this study allowed the establishment of haplotypes found in the forensic samples of Bahia State to serve as a reference in the elucidation of criminal cases and paternity tests, as well as population and evolutionary investigations.

show abstract

Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Allele Frequencies and Forensic Data of 25 STR Markers for Individuals in Northeast Brazil

Santos

Filho

Silva

et al. 2023

Genes

View full text Add to dashboard Cite

show abstract

“…However, the MTHFR C677T and A1298C polymorphisms did not differ significantly between groups in this study. This fact can be explained by two reasons, (1) the sample size is small and (2) the mixing occurred in the region, since the northeast Brazilian population was originated from African, Caucasian and Native American ancestral individuals [25]. According to Volcik et al (2001) the frequencies of alleles 677 T and A1298C may vary according to geographical area and ethnic group and the difference of values observed among populations can be explained by ethnic differences and nutrition [26].…”

Section: Discussionmentioning

confidence: 99%

Plasmatic higher levels of homocysteine in Non-alcoholic fatty liver disease (NAFLD)

Carvalho

Muniz

Siqueira

et al. 2013

Nutr J

Self Cite

View full text Add to dashboard Cite

BackgroundNon-alcoholic fatty liver disease (NAFLD) is a chronic liver disease, which includes a spectrum of hepatic pathology such as simple steatosis, steatohepatitis, fibrosis and cirrhosis. The increased serum levels of homocysteine (Hcy) may be associated with hepatic fat accumulation. Genetic mutations in the folate route may only mildly impair Hcy metabolism. The aim of this study was to investigate the relation between liver steatosis with plasma homocysteine level and MTHFR C677T and A1298C polymorphisms in Brazilian patients with NAFLD.MethodsThirty-five patients diagnosed with NAFLD by liver biopsy and forty-five healthy controls neither age nor sex matched were genotyped for C677T and A1298C MTHFR polymorphisms using PCR-RFLP and PCR-ASA, respectively, and Hcy was determined by HPLC. All patients were negative for markers of Wilson’s, hemochromatosis and autoimmune diseases. Their daily alcohol intake was less than 100 g/week. A set of metabolic and serum lipid markers were also measured at the time of liver biopsies.ResultsThe plasma Hcy level was higher in NAFLD patients compared to the control group (p = 0.0341). No statistical difference for genotypes 677C/T (p = 0.110) and 1298A/C (p = 0.343) in patients with NAFLD and control subjects was observed. The genotypes distribution was in Hardy-Weinberg equilibrium (677C/T p = 0.694 and 1298 A/C p = 0.188). The group of patients and controls showed a statistically significant difference (p < 0.001) for BMI and HOMA_IR, similarly to HDL cholesterol levels (p < 0,006), AST, ALT, γGT, AP and triglycerides levels (p < 0.001). A negative correlation was observed between levels of vitamin B12 and Hcy concentration (p = 0.005).ConclusionOur results indicate that plasma Hcy was higher in NAFLD than controls. The MTHFR C677T and A1298C polymorphisms did not differ significantly between groups, despite the 677TT homozygous frequency was higher in patients (17.14%) than in controls (677TT = 4.44%) (p > 0.05). The suggested genetic susceptibility to the MTHFR C677T and A1298C should be confirmed in large population based studies.

show abstract